Evidence map›Paper›PMID 40839658›Full record

ArticlePloS one2025

Effect of upper limb isometric training (ULIT) on hamstring strength in early postoperative anterior cruciate ligament reconstruction patients: Study protocol for a randomized controlled trial.

Efri Noor Muhamad Hendri, Mohamad Shariff A Hamid, Badrul Akmal Hisham Md Yusoff, Norlelawati Mohamad, Ashril Yusof

Abstract readClinical Trial Protocol
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Efri Noor Muhamad HendriDepartment of Orthopedics and Traumatology, Hospital Canselor Tuanku Muhriz, National University of Malaysia, Kuala Lumpur, Malaysia.
Mohamad Shariff A HamidDepartment of Sports Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.ORCID https://orcid.org/0000-0001-9196-0442
Badrul Akmal Hisham Md YusoffDepartment of Orthopedics and Traumatology, Hospital Canselor Tuanku Muhriz, National University of Malaysia, Kuala Lumpur, Malaysia.
Norlelawati MohamadDepartment of Orthopedics and Traumatology, Hospital Canselor Tuanku Muhriz, National University of Malaysia, Kuala Lumpur, Malaysia.
Ashril YusofFaculty of Sports and Exercise Science, Universiti Malaya, Kuala Lumpur, Malaysia.ORCID https://orcid.org/0000-0002-8117-6440

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anterior cruciate ligament (ACL) injuries impact approximately 68.6 per 100,000 individuals annually, with ACL reconstruction (ACLR) being a common intervention for restoring knee stability in physically active individuals. Despite advancements in surgical techniques and rehabilitation protocols, patients often experience prolonged recovery, hamstring weakness, and neuromuscular deficits, increasing the risk of re-injury and osteoarthritis. Early-phase ACLR rehabilitation primarily focuses on managing pain, swelling, and quadriceps strength, frequently neglecting the critical role of hamstrings in knee stabilization. This leaves a gap in addressing imbalances that hinder functional recovery and return-to-sport timelines. Upper limb isometric training (ULIT) presents an innovative approach to enhance hamstring activation during the early rehabilitation phase. By leveraging the posterior myofascial kinetic chain (PMKC), ULIT indirectly stimulates hamstrings through bilateral static upper limb exercises, such as wall push up, shoulder extension and scapular retraction, promoting neuromuscular coordination and kinetic chain synergy. These exercises mitigate challenges associated with direct hamstring loading, such as arthrogenic muscle inhibition and graft protection needs. Preliminary research suggests upper limb resistance exercise at submaximal voluntary contraction facilitates inter-limb strength gains, improves core abdominals and hamstring activation, and reduces knee imbalances, supporting accelerated recovery and reduced re-injury risk. The ULIT demonstrates potential as an alternative warm-up exercise to promote hamstring activation and enhance overall readiness for physical activity. Emerging findings highlight ULIT as a safe and potentially effective supplementary intervention, but further research is essential to establish its role in ACLR rehabilitation and develop evidence-based protocols. This study aims to evaluate the effects of integrating ULIT into standard care rehabilitation on hamstring strength and physical function in early-phase postoperative ACLR patients with hamstring autograft. The findings could introduce a novel and effective strategy to optimize recovery, enhance functional outcomes, and support a safer return to sport. Trial registration number: ACTRN12624001445561 and available at https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=388441&isReview=true.

Indexed as

Anterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionExercise TherapyHamstring MusclesMuscle StrengthUpper ExtremityAdultFemaleHumansIsometric ContractionMaleRandomized Controlled Trials as TopicRecovery of FunctionYoung Adult

Identifiers

PMID40839658
PMCPMC12370102

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.