ArticlePloS one2025
Invasive candidiasis following lung transplant: An Assessment of impact utilizing a national insurance claims cohort.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- An Update on Invasive Fungal Infections in Solid Organ Transplant Recipients.Transplant infectious disease : an official journal of the Transplantation SocietyReview
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLung transplant recipients (LTRs) are susceptible to invasive candidiasis (IC). This study aimed to assess the incidence, risk factors, and impact of IC on mortality in LTRs using a national insurance claims cohort.
methodsWe conducted a retrospective cohort study using administrative claims data from the OptumLabs® Data Warehouse. We identified LTRs from January 1, 2005, to December 31, 2023, using procedural codes. Exclusion criteria included re-transplantations and pre-transplant IC. We employed multivariable logistic regression to identify risk factors for IC and Cox Proportional Hazard models to assess the impact of IC on mortality.
resultsAmong 1279 LTRs, 131 (10.2%) developed IC, primarily during the initial hospitalization for lung transplantation (index hospitalization). The median time to IC diagnosis was 32.0 days following transplant. Post-transplant extra-corporeal membrane oxygenation (ECMO) for more than 8 days was associated with IC (OR: 2.34; 95% CI 1.03 to 5.34). Mortality was higher in LTRs with IC (HR: 2.31; 95% CI: 1.45 to 3.67; p < 0.001). LTRs with IC also had longer hospital stays (median 26.0 days vs. 20.0 days; p < 0.001) and more re-operations (36.7% vs. 27.3%; p = 0.003) compared to those without IC.
conclusionInvasive candidiasis affects approximately 10% of lung transplant recipients, most often during the initial hospitalization. It is associated with increased mortality, prolonged hospital stays, and a greater need for surgical re-intervention. These findings highlight the importance of early identification and targeted preventive strategies to improve outcomes in this high-risk population.
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