Exploring the Potential of Chemically Matched Fragments as Internal Standards for Quantitative SERS with Panobinostat.

Yiming Huang, Yikai Xu, Chunchun Li, Steven E J Bell

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Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Yiming HuangSchool of Chemistry and Chemical Engineering, Queen's University, David Keir Building, Stranmillis Road, Belfast BT9 5AG, U.K.

Yikai XuKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.ORCID 0000-0003-3881-8871

Chunchun LiSchool of Materials Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.ORCID 0000-0001-9501-0313

Steven E J BellSchool of Chemistry and Chemical Engineering, Queen's University, David Keir Building, Stranmillis Road, Belfast BT9 5AG, U.K.ORCID 0000-0003-3767-8985

Funding

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6 · The paper itself

Abstract

Surface-enhanced Raman spectroscopy (SERS) has great potential for therapeutic drug monitoring (TDM) due to its high sensitivity; however, achieving accurate and robust quantitative data remains challenging. The most effective approach for quantitative SERS is to use internal standards (IS). Isotopologues are particularly effective; however, these or closely related analogues of the target compound are often unavailable. We have addressed this problem by using fragments of the target compound as the IS. Here, 2-methylindole (2-MI) was identified as the most suitable fragment for Panobinostat (Pano). Tests with an enhancing colloid that degraded significantly over a 4-week period showed that the 2-MI IS allowed changes in the absolute intensity of the Pano signal over time to be corrected and that the standard error achieved with the degrading enhancing medium matched that of results obtained with the fresh colloid. The calibration range could be extended by using either low (4 × 10

Identifiers

PMID40839542

DOI10.1021/acs.analchem.5c02017

PMCPMC12409699

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