ArticleJournal of diabetes investigation2025
Dysregulation of miR-21-5p in diabetic nephropathy and its role in inflammatory response.
Article in Journal of diabetes investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Overexpression of LINC00472 alleviates diabetic kidney disease progression via the miR-21-5p/STAT3 axis.Renal failure · 2026Article
- Letter to the Editor in response to the article "Dysregulation of miR-21-5p in diabetic nephropathy and its role in inflammatory response".Journal of diabetes investigation · 2026Article
- Research progress on the mechanism, diagnosis, and treatment of exosomal miRNA in chronic prostatitis.Frontiers in immunology · 2026Review
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Authors and funding
3 authors.
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Abstract
backgroundDiabetic nephropathy (DN) is an important microvascular complication of diabetes. MicroRNAs play an important role in the development of DN.
aimsThis study aims to examine the expression and clinical significance of serum miR-21-5p in patients with type 2 diabetes mellitus (T2DM) and DN.
methodsThis study enrolled a total of 106 T2DM patients, 106 T2DM patients with DN, and 70 healthy individuals. Real-time fluorescence quantitative PCR (RT-qPCR) was used to detect the expression of miR-21-5p, and the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of miR-21-5p in DN. Pearson correlation analysis was performed to examine the association between miR-21-5p levels and estimated glomerular filtration rate (eGFR), urinary protein excretion rate (UAER) and other clinicopathological parameters of glomerulonephritis. Furthermore, the effects of miR-21-5p on the function and inflammation of human glomerular mesangial cells (HMCs) were analyzed.
resultsSerum miR-21-5p is upregulated in DN and it can effectively distinguish DN patients from T2DM patients. Pearson correlation analysis showed a negative correlation between miR-21-5p and eGFR and a positive correlation with UAER. Finally, the knockdown of miR-21-5p reduced the levels of pro-inflammatory cytokines induced by high glucose (HG) and the proliferation of HMCs.
conclusionsSerum miR-21-5p is upregulated in DN and it might be a diagnostic marker for DN. Furthermore, miR-21-5p may be involved in the occurrence and progression of DN by regulating cell proliferation and inflammatory responses and is expected to become a potential therapeutic target for DN.
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