ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2026
Co-occurring pediatric chronic pain and mental health: A genetically informed study.
Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Adolescent pain reports share genetic overlap with adult chronic pain conditions: A polygenic score analysis using the ABCD study.The journal of pain · 2026Article
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3 authors.
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Abstract
objectivePediatric chronic pain is pervasive and associated with myriad adverse consequences, yet due consideration has not been given to the mental health disturbances that often present alongside chronic pain and the etiological mechanisms that potentially underlie both. The current study examined the genetic and environmental etiology underlying chronic pain and internalizing symptomology in middle childhood, considering both independent and co-occurring symptom presentations.
methodThe sample comprised 795 children (399 families;
resultsThe results indicated that chronic pain was highly heritable (78%). Internalizing symptomology was modestly heritable (32%) and further subject to moderate shared environmental influence (50%). Moreover, 9% of the variance in chronic pain was explained by additive genetic factors shared with internalizing symptomology.
conclusionsIn middle childhood, chronic pain and internalizing symptoms are largely distinct, with shared genetic influences accounting for their co-occurrence, supporting the idea that comorbidity increases with age via transactional influences. Results provide novel insight into common liabilities underlying pediatric chronic pain and internalizing symptoms. (PsycInfo Database Record (c) 2026 APA, all rights reserved).
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