Review in American journal of physiology. Lung cellular and molecular physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
6 authors.
Navneet SinghDepartment of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Warren Alpert School of Medicine at Brown University, Providence, Rhode Island, United States.ORCID 0000-0001-8058-3004
Ceren KoçanaInstitute of Physiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0001-5863-2447
Eric P SchmidtDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Mass General Brigham, Harvard Medical School, Boston, Massachusetts, United States.ORCID 0000-0002-7360-0504
Mark L HepokoskiDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California San Diego, San Francisco, California, United States.ORCID 0000-0002-9267-9262
Michael A MatthayDepartment of Anesthesia and Perioperative Care, Critical Care Medicine, University of California San Francisco, San Francisco, California, United States.ORCID 0000-0003-3039-8155
Troy StevensDepartment of Physiology and Cell Biology, Center for Lung Biology, University of South Alabama, Mobile, Alabama, United States.ORCID 0000-0001-9689-929X
Funding
Sulfs and Injury Repair in Mucosal EpitheliaP01AI053194 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ENGEL, JOANNE N. · 2002 to 2012
$13.4M
1/1: ARREST RESPIRATORY FAILURE DUE TO PNEUMONIA (ARREST PNEUMONIA)UH3HL141722 · NHLBI · STANFORD UNIVERSITY · PI FESTIC, EMIR, GAJIC, OGNJEN · 2020 to 2023
$7.8M
Vascular mechanisms of sepsis-induced cognitive dysfunctionR01HL168892 · NHLBI · OHIO STATE UNIVERSITY · PI Paco S Herson, Eric Peter Schmidt · 2023 to 2026
$2.8M
Cellular and molecular mapping of ventilator-induced lung injuryR01HL170601 · NHLBI · STANFORD UNIVERSITY · PI Tushar Jasubhai DESAI, MICHAEL A. MATTHAY · 2024 to 2026
$2.0M
Soluble adenylyl cyclases in lung endothelial tauopathyR01HL167997 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI Troy Stevens · 2023 to 2026
$1.9M
The Impact of Fluid Resuscitation on Glycocalyx Degradation in Septic ShockR01HL149422 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SCHMIDT, ERIC PETER, SHAPIRO, NATHAN I · 2019 to 2022
$1.7M
Lung Endothelial Aß in infectious proteinopathyR01HL148069 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI STEVENS, TROY · 2020 to 2023
$1.5M
Mechanisms of acute kidney injury due to mechanical ventilationR01DK136756 · NIDDK · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI Mark Lawrence Hepokoski · 2024 to 2026
$1.4M
Optimization of a rapid assay to quantify circulating glycosaminoglycans and identify vascular endotypes of sepsisR21GM151565 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI SCHMIDT, ERIC PETER, SHAPIRO, NATHAN I · 2023 to 2024
$480k
American Thoracic Society (ATS)BLRD VA I01 BX006238Calif Regenerative Medicine + Roche-Genentech and Quantum TherapeuticsDeutsche Forschungsgemeinschaft (DFG) Project-ID 437531118-SFB-1470 - A04HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL148069HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL149422HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL167997HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL168892HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL170601HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) UH3HL141722HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) P01AI053194HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK136756HHS | NIH | National Institute of General Medical Sciences (NIGMS) R21GM151565NHLBI NIH HHS R01 HL148069NHLBI NIH HHS R01 HL149422NHLBI NIH HHS R01 HL167997NHLBI NIH HHS R01 HL168892NHLBI NIH HHS R01 HL170601NHLBI NIH HHS UH3 HL141722NIAID NIH HHS P01 AI053194NIDDK NIH HHS R01 DK136756NIGMS NIH HHS R21 GM151565U.S. Department of Defense (DOD) W81XWH-17-1-0631U.S. Department of Veterans Affairs (VA) BX006238
6 · The paper itself
Abstract
Session V of the inaugural biennial Research Symposium on Pulmonary Injury and Repair of the Endothelium showcased cutting-edge research on pulmonary endothelial crosstalk with end organs and its role in vascular disease. Growing evidence suggests that communication between injured organs and distal vascular beds plays a critical role in the pathogenesis of complex conditions such as sepsis, acute respiratory distress syndrome, pulmonary arterial hypertension, and heart failure with preserved ejection fraction. Circulating mediators-including heparan sulfate fragments, proinflammatory cytokines, mitochondrial damage-associated molecular patterns, bone morphogenetic protein 9, bile acids, and nitric oxide-have emerged as key factors linking pulmonary endothelial dysfunction to neural impairment, acute kidney injury, subclinical liver injury, and left-sided heart disease. This review highlights recent advances in the field, identifies critical knowledge gaps, and outlines future research directions aimed at elucidating mechanisms of multiorgan dysfunction and identifying novel therapeutic targets.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Mechanisms of lung crosstalk with end organs: scientific session V-ReSPIRE 2025. · full record | OpenQuestion