Evidence map›Paper›PMID 40839377›Full record

ArticleJAMA ophthalmology2025

Outcomes of Trabeculectomy With Mitomycin C in Patients of Hispanic vs European Descent.

Sajad Besharati, Vahid Mohammadzadeh, Maryam Ashrafkhorasani, Golnoush Mahmoudinezhad, Ziyue Hu, Mahshad Rafiei, Alaiza Guerrero, Judy Figueroa, Anne L Coleman, JoAnn Giaconi and 4 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in JAMA ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Two-year efficacy and safety outcomes of the Paul Glaucoma Implant compared to the Ahmed Glaucoma Valve.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Sajad BesharatiGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles.
Vahid MohammadzadehGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles.
Maryam AshrafkhorasaniGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles.
Golnoush MahmoudinezhadGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles.
Ziyue HuDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles.
Mahshad RafieiGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles.
Alaiza GuerreroGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles.
Judy FigueroaGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles.
Anne L ColemanGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles.
JoAnn GiaconiGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles.
Simon K LawGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles.
Zhe FeiDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles.
Joseph CaprioliGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles.
Kouros Nouri-MahdaviGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Importance: Previous studies suggest that race or ethnicity may influence glaucoma surgical outcomes. Objective: To compare outcomes of initial trabeculectomy with mitomycin C (MMC) in patients of Hispanic descent with those in patients of European descent and identify prognostic factors for failure. Design, Setting, and Participants: This retrospective matched-cohort study was conducted at a single-tertiary academic center. The study included 111 eyes from 96 patients of Hispanic descent that were matched to 111 eyes from 108 patients of European descent, based on age (±5 years), surgeon, lens status, and surgery date (±1 year). Ethnicity was self-determined by patients. Exposure: Initial trabeculectomy with MMC. Main Outcome Measures: Criteria A, B, and C defined qualified success as final intraocular pressure (IOP) of 18 mm Hg or less, 15 mm Hg or less, and 12 mm Hg or less, respectively, with corresponding IOP reduction of 20% or more, 25% or more, and 30% or more, or a decrease of 2 or more medications. Complete success required meeting the above criteria without medication use. Kaplan-Meier survival curves compared patients of Hispanic descent and patients of European descent success rates with log-rank tests. Cox proportional hazard models estimated the influence of ethnicity on surgical success adjusting for confounders. Results: The Hispanic descent cohort included 59 females (61.5%) and 37 males (38.5%) with a mean (SD) age of 69.1 (9.9) years. The European descent cohort included 53 females (49.1%) and 55 males (50.9%) with a mean (SD) age of 69.2 (9.4) years. Qualified success rates at 5 years in Hispanic descent and European descent patients were 52% and 68% based on criteria A (difference, 16.7%; 95% CI, 4.0%-29.4%; P < .001), 45% and 61% according to criteria B (difference, 16.2%; 95% CI, 3.2%-29.1%; P = .01), and 31% and 51% based on criteria C (difference, 20.0%; 95% CI, 7.3%-32.6%; P = .002). On multivariable analyses, Hispanic descent was associated with higher failure rates with all complete and qualified success criteria (hazard ratio range, 2.07-3.03; P < .001). Early bleb leaks were more frequent in patients of Hispanic descent (14 eyes vs 6 eyes; P = .10). Conclusion and Relevance: In this study, Hispanic descent was associated with higher failure rate after initial trabeculectomy with adjunctive MMC compared with European descent. These findings need to be considered when glaucoma surgery is contemplated in patients of Hispanic descent, especially if these findings are confirmed in future studies that address some of the limitations of this single-center retrospective investigation.

Indexed as

Alkylating AgentsGlaucomaGlaucoma, Open-AngleHispanic or LatinoMitomycinTrabeculectomyWhiteAgedCombined Modality TherapyFemaleHumansIntraocular PressureMaleMiddle AgedRetrospective StudiesTreatment OutcomeAlkylating AgentsMitomycin

Identifiers

PMID40839377
PMCPMC12371543

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.