Evidence map›Paper›PMID 40839326›Full record

ReviewApoptosis : an international journal on programmed cell death2025

The role of epigenetic regulation in cuproptosis, ferroptosis and NETosis in the pathogenesis of autoimmune diseases.

Wenshan Zhao, Leping Wang, Hanru Jia, Jiali Shan, Yi Zhang, Hejia Gu, Yongchao Xu, Xinke Ma, Peiying Li, Jing Wu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Apoptosis : an international journal on programmed cell death, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wenshan Zhao *Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogenic Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 311121, China.
Leping Wang *Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogenic Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 311121, China.
Hanru Jia *Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogenic Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 311121, China.
Jiali ShanZhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogenic Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 311121, China.
Yi ZhangZhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogenic Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 311121, China.
Hejia GuZhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogenic Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 311121, China.
Yongchao XuZhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogenic Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 311121, China.
Xinke MaZhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogenic Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 311121, China.
Peiying LiZhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogenic Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 311121, China.
Jing WuZhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogenic Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, 311121, China. wu.jing@hznu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis, cuproptosis and NETosis are various important forms of non-apoptotic programmed cell death, with research involving these subtypes of cell death exponentially increased in recent years. Ferroptosis is a unique iron-dependent form of cell death that involves iron transport as well as redox homeostasis within the cell. Cuproposis is a new phenomenon of cell death, primarily driven by the excessive intracellular accumulation of copper ions, with its occurrence and development closely associated with mitochondrial dysfunction. NETosis on the other hand occurs due to the release of neutrophil extracellular traps by neutrophils upon their stimulation. Currently, various of types of autoimmune diseases (AD) have been clinically identified, with their etiology established to be multifactorial. In this review, we specifically investigate the correlation between these three non-apoptotic programmed cell deaths and the pathogenesis of AD, as well as elucidate the internal mechanisms involving miRNA, DNA methylation, histone modifications, related transcription factors, and non-coding RNAs from an epigenetic perspective. Additionally, we analyzed the molecular and pathophysiological mechanisms of ferroptosis, cupropopsis, and NETosis in the development of AD. By examining the therapeutic potential of emerging immune checkpoint targets, this review aims to offer novel insights and strategies to address the ongoing challenges in the prevention and treatment of autoimmune diseases.

Indexed as

Autoimmune DiseasesCopperEpigenesis, GeneticExtracellular TrapsFerroptosisAnimalsDNA MethylationHumansNeutrophilsCopperAutoimmune diseasesCuproptosisEpigeneticsFerroptosisNETosis

Identifiers

PMID40839326

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.