ReviewTopics in current chemistry (Cham)2025
Total Syntheses of Deuterated Drugs: A Comprehensive Review.
Review in Topics in current chemistry (Cham), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Gene Expression Patterns in Lung Adenocarcinoma Cells in Response to Changes in Deuterium Concentration.International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deuterium is a safe bioisostere of hydrogen, and its selective labeling has a great prominence in medicinal chemistry for the amelioration of the pharmacokinetic profiles of the drugs. The deuterium-labeled pharmaceutically active compounds have been observed to exhibit broad applications, either as deuterated drugs or as pharmacokinetic probes (biomarkers). The deuterated drugs offer improved bioactivity and metabolic profile in terms of tolerability, efficacy, and reduced toxicity. In this manuscript, the synthetic strategies of various deuterated drugs including antiviral, anticancer, antiarrhythmic, antidiabetic, anticholinergic, antibiotics, antidepressants, and antipyretics have been documented. In addition, this review article also comprises a broad class of miscellaneous drugs i.e., antiasthmatic drugs, antiseptics, topical analgesics, antifibrotic agents, immunosuppressants, and central nervous system (CNS) suppressants. Additionally, the synthesis of several deuterated pharmaceutically active compounds as biomarkers has also been compiled in this review. Leveraging the modern platform of precision deuteration, this review article provides a repertoire of synthetic strategies for the synthesis of several deuterated drugs reported over a period of 2005-2024 (two decades).
Indexed as
Identifiers
40839291What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.