Evidence map›Paper›PMID 40839242›Full record

ArticleJournal of neuro-oncology2025

Gamma knife radiosurgery for breast cancer brain metastasis: survival outcomes, prognotic factors, and the role of repeat treatment.

Ching-Ying Wang, Chun-Fu Lin, Huai-Che Yang, Chun-Yu Liu, Jiun-I Lai, Hsiu-Mei Wu, Wen-Yuh Chung, Cheng-Ying Shiau, Wan-Yuo Guo, Cheng-Chia Lee

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ching-Ying WangDepartment of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Chun-Fu LinDepartment of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Huai-Che YangDepartment of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Chun-Yu LiuSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Jiun-I LaiSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Hsiu-Mei WuSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Wen-Yuh ChungDepartment of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Cheng-Ying ShiauSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Wan-Yuo GuoSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Cheng-Chia LeeDepartment of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan. yfnaughty@gmail.com.

Funding

Ministry of Science and Technology, Taiwan MOST 110-2314-B075-038-MY2
6 · The paper itself

Abstract

purposeThis study evaluated prognostic factors and longitudinal outcomes associated with gamma knife radiosurgery (GKRS) in treating brain metastases from breast cancer, and assessed the efficacy of repeated GKRS in prolonging intracranial disease control.

methodsIn this retrospective study, we reviewed 159 breast cancer patients involving 640 brain metastases who underwent GKRS at a tertiary medical center. Overall survival (OS), local control (LC), and distant intracranial control were estimated using the Kaplan-Meier method. Prognostic factors were estimated using Cox regression models. The effect of repeat GKRS on intracranial disease control was also examined.

resultsThe median OS was 19.2 months. In multivariate analysis, the Karnofsky Performance Scale (KPS), HER2 positivity, and ER/PR positivity were independently associated with longer survival. LC rates were 88.9% at 6 months and 83.0% at 12 months. Factors significantly associated with improved LC included a higher margin dose, HER2-negative status, smaller tumor volume, and absence of prior whole-brain radiotherapy (WBRT). Distant intracranial failure within 12 month occurred in 57.0% of patients. Median intracranial control among the 44 patients who underwent repeated GKRS (28.1 months) was significantly longer than those who received single GKRS (8.0 months; p < 0.001).

conclusionGKRS provides effective local tumor control and favorable survival outcomes for patients with breast cancer brain metastases. KPS score and receptor status (ER/PR and HER2) are significant predictors of overall survival. Repeat GKRS is a promising strategy for prolonging intracranial control and may reduce the need for WBRT or surgical intervention in selected patients.

Indexed as

Brain NeoplasmsBreast NeoplasmsRadiosurgeryAdultAgedAged, 80 and overErb-b2 Receptor Tyrosine KinasesFemaleFollow-Up StudiesHumansKaplan-Meier EstimateMiddle AgedPrognosisRetrospective StudiesTreatment OutcomeErb-b2 Receptor Tyrosine KinasesBrain metastasesBreast cancerGamma knife radiosurgery

Identifiers

PMID40839242

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.