Evidence map›Paper›PMID 40839240›Full record

ArticleBehavior genetics2025

Education as a Modifier of Genetic Influence on Cognitive Ability in Older Adults.

Yu-Cheng Hsu, Mei-Chen Lin, Mei-Hsin Su, Chi-Fung Cheng, Yi-Jiun Pan, Chun Chieh Fan, Chia-Yen Chen, Chi-Shin Wu, Shi-Heng Wang

Abstract read
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In one paragraph

Article in Behavior genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yu-Cheng HsuDepartment of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.
Mei-Chen LinNational Center for Geriatrics and Welfare Research, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County 350, Zhunan, Taiwan.
Mei-Hsin SuDepartment of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.
Chi-Fung ChengNational Center for Geriatrics and Welfare Research, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County 350, Zhunan, Taiwan.
Yi-Jiun PanDepartment of Microbiology and Immunology, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Chun Chieh FanCenter for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, OK, USA.
Chia-Yen ChenBiogen, Cambridge, MA, USA.
Chi-Shin WuNational Center for Geriatrics and Welfare Research, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County 350, Zhunan, Taiwan.
Shi-Heng WangNational Center for Geriatrics and Welfare Research, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County 350, Zhunan, Taiwan. shwang@nhri.edu.tw.

Funding

National Health Research Institutes CG-112-GP-10, CG-113-GP-10, CG-114-GP-10, NHRI-EX109-10931PI, NHRI-EX110-10931PI, NHRI-EX111-10931PINational Science and Technology Council NSTC111-2628-B-400-004-MY3
6 · The paper itself

Abstract

Whether education modifies genetic influences on cognition has not been fully explored, especially in non-European populations. Using the older adult cohort from the Taiwan Biobank of East Asian populations, this study aimed to investigate the modifying effect of education on the association of the apolipoprotein E (APOE) ε4 allele and polygenic scores (PGS) for Alzheimer's disease (PGS

Indexed as

Alzheimer DiseaseCognitionEast Asian PeopleEducational StatusSchizophreniaAgedAllelesApolipoprotein E4Apolipoproteins ECohort StudiesFemaleHumansMaleMental Status and Dementia TestsMiddle AgedMultifactorial InheritanceApolipoprotein E4Apolipoproteins EAPOE ε4Cognitive abilityEducationModifying effectPolygenic score

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.