ArticleJournal of Crohn's & colitis2025
Assessing intestinal fibrosis using an endoscopic photoacoustic-ultrasound balloon catheter in rabbits and a human subject.
Article in Journal of Crohn's & colitis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- From lab design to clinical translation: photoacoustic endoscopy.Photoacoustics · 2026Review
- Artifact-suppressed dual-modality OCT-fluorescence endoscopic imaging of colitis in murine models.Biomedical optics express · 2026Article
- Characterizing Muscle Components in Intestinal Strictures Using Spectroscopic Photoacoustic Imaging.Journal of biophotonics · 2026Article
- Translational photoacoustic and ultrasound imaging catheter for characterizing gastrointestinal inflammation and fibrosis: a study with a pig modelBiomedical optics express · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
BACKGROUND AND
aimsAssessment of fibrosis in intestinal strictures in Crohn's disease (CD) could contribute to clinical decision-making. Our recent studies demonstrated that endoscopic photoacoustic (PA) imaging can quantify the progression of intestinal fibrosis based on its collagen content and its mechanical stiffness. The aim of this study was to evaluate the feasibility and diagnostic reliability of a PA-ultrasound balloon catheter in assessing intestinal fibrosis.
methodsAcute colonic colitis or chronic inflammation with fibrosis was induced in rabbits using intrarectal trinitrobenzene sulfonic acid. The affected distal colon was assessed through PA imaging in vivo and microelastometry ex vivo. Quantitative measurements were derived from the images and compared with histopathology. We also examined the feasibility of the catheter in a human subject with CD strictures.
resultsQuantitative PA imaging measurements in vivo detected an increased collagen/hemoglobin ratio of 1.42 arbitrary units (P < .001) in the chronic high fibrosis rabbit group compared to the acute colitis/low fibrosis and normal groups. The imaging results in vivo also showed an increased relative tissue stiffness of 4.27 kPa (P < .001) in the high fibrosis group compared to the low fibrosis and normal groups, which agrees with ex vivo microelastometer measurements. The human subject study demonstrates sufficient light penetration and signal-to-noise ratio for assessing intestinal fibrosis during a standard ileo-colonoscopy procedure.
conclusionOur novel imaging catheter shows reliability in differentiating the changes in molecular components and mechanical properties during the progression of intestinal fibrosis. This catheter-based approach is fully compatible with clinical colonoscopy procedures.
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