Evidence map›Paper›PMID 40839165›Full record

ReviewDocumenta ophthalmologica. Advances in ophthalmology2025

ISCEV standard for clinical visual evoked potentials (2025 update).

M Šuštar Habjan, M Bach, M M van Genderen, S Li, A Mizota, J Nilsson, D A Thompson, A G Robson

Abstract readReview
In one paragraph

Review in Documenta ophthalmologica. Advances in ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Visual evoked potential abnormalities in spinocerebellar ataxia type 27B: a case report.Documenta ophthalmologica. Advances in ophthalmology · 2026
    Article
  5. Article
  6. Clinical endpoints special session, ISCEV 2025, Utrecht.Documenta ophthalmologica. Advances in ophthalmology · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Sex-independent visual evoked potential complexity.Clinical neurophysiology practice · 2026
    Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M Šuštar HabjanEye Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia.
M BachEye Center, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
M M van GenderenDepartment of Ophthalmology, University Medical Centre Utrecht, Utrecht, The Netherlands.
S LiDepartment of Ophthalmology, First Affiliated Hospital of Xiamen University, School of Medicine, Eye Institute of Xiamen University, Fujian Province, China.
A MizotaDepartment of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan.
J NilssonDepartment of Clinical Neurophysiology, Sahlgrenska University Hospital, Göteborg, Sweden.
D A ThompsonThe Tony Kriss Visual Electrophysiology Unit, Clinical and Academic Department of Ophthalmology, Sight and Sound Centre, Great Ormond Street Hospital for Children NHS Trust, London, UK.
A G RobsonDepartment of Electrophysiology, Moorfields Eye Hospital, London, UK. anthony.robson3@nhs.net.ORCID 0000-0002-8391-6123

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Visual evoked potentials (VEPs) are electrophysiologic responses to pattern or flash stimuli, recorded over the occiput. VEPs can provide information regarding the function of the visual system and are valuable in the diagnosis and investigation of optic nerve disease or post-retinal visual pathway dysfunction. The ISCEV VEP Standard specifies stimulus and recording conditions for three basic types of recording: (1) Pattern-reversal VEPs elicited by checkerboard stimuli with large 1° (degree) and small 0.25° check widths. (2) Pattern onset/offset VEPs elicited by checkerboard stimuli with large 1° and small 0.25° check widths. (3) Flash VEPs elicited by a flash which subtends a visual field of at least 20°. The ISCEV VEP Standard protocols are defined for a single recording channel with a midline occipital active electrode. Multi-channel VEPs for evaluation of chiasmal and post-chiasmal lesions, together with protocols specific for pediatric populations, are also described in this document as non-standardized additions. The main changes in the updated ISCEV Standard for clinical VEP include an option to perform a simultaneous pattern electroretinogram (PERG) and pattern-reversal VEP recording, a revised definition of the origin and the analysis of the most prominent VEP components, and more precise descriptions of non-standard multi-channel and pediatric VEP recordings, intended to encourage convergence of widely used non-standard methods. These changes aim to provide a clinically relevant document about current practice which will facilitate good quality recordings and inter-laboratory comparisons.

Indexed as

Evoked Potentials, VisualOptic Nerve DiseasesElectroretinographyHumansPhotic StimulationVisual PathwaysClinical standardsFlash visual evoked potentialInternational Society for Clinical Electrophysiology of Vision (ISCEV)Pattern onset/offset visual evoked potentialPattern-reversal visual evoked potentialVisual evoked potential (VEP)

Identifiers

PMID40839165
PMCPMC12436483

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.