Evidence map›Paper›PMID 40839119›Full record

ArticleThe British journal of radiology2025

Long-term oncological outcomes following percutaneous microwave ablation of T1 renal cell carcinoma.

Luke Glover, Joseph John, Alexander Spiers, Richard Guinness, Thomas Dutton, Andrew Gemmell, Rajinder Virdi, Jonathan Skinner, Moira Anderson, Taona Stainer-Smith and 1 more

Abstract read
In one paragraph

Article in The British journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Luke GloverDepartment of Medical Imaging, Royal Devon University Healthcare NHS Foundation Trust, Exeter EX2 5DW, United Kingdom.ORCID 0000-0002-6059-722X
Joseph JohnDepartment of Urology, Royal Devon University Healthcare NHS Foundation Trust, Exeter EX2 5DW, United Kingdom.
Alexander SpiersDepartment of Medical Imaging, Royal Devon University Healthcare NHS Foundation Trust, Exeter EX2 5DW, United Kingdom.
Richard GuinnessDepartment of Medical Imaging, Royal Devon University Healthcare NHS Foundation Trust, Exeter EX2 5DW, United Kingdom.
Thomas DuttonDepartment of Urology, Royal Devon University Healthcare NHS Foundation Trust, Exeter EX2 5DW, United Kingdom.
Andrew GemmellDepartment of Medical Imaging, Royal Devon University Healthcare NHS Foundation Trust, Exeter EX2 5DW, United Kingdom.
Rajinder VirdiDepartment of Medical Imaging, Royal Devon University Healthcare NHS Foundation Trust, Exeter EX2 5DW, United Kingdom.
Jonathan SkinnerDepartment of Medical Imaging, Royal Devon University Healthcare NHS Foundation Trust, Exeter EX2 5DW, United Kingdom.
Moira AndersonDepartment of Urology, Royal Devon University Healthcare NHS Foundation Trust, Exeter EX2 5DW, United Kingdom.
Taona Stainer-SmithDepartment of Urology, Royal Devon University Healthcare NHS Foundation Trust, Exeter EX2 5DW, United Kingdom.
Nicholas CampainDepartment of Urology, Royal Devon University Healthcare NHS Foundation Trust, Exeter EX2 5DW, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIncidence of small renal masses (SRMs) including renal cell carcinoma (RCC) is increasing. Standard of care is to offer partial nephrectomy (PN), with tumour ablation (TA) considered an alternative in frail/co-morbid patients. This study aimed to determine whether microwave ablation (MWA) is a safe and effective treatment for selected cases of RCC.

methodsAll MWAs performed at a regional tertiary care centre between October 2016 and April 2024 were prospectively recorded on a database. Data collected included tumour and patient characteristics, complications, and recurrences.

resultsTwo hundred and nine MWAs were recorded with median 37 months (interquartile range [IQR] 15.3-59.4 months) follow-up. About 94.7% of patients had ≥12 months of follow-up. The biopsy rate was 92%. Following MWA, 93% of patients had a hospital stay of 1 night. Two Clavien-Dindo grade ≥III complications occurred within 30 days (0.96%). Local and metastatic recurrence rates were 5.9% and 2.7%, respectively.

conclusionsMWA was a safe, effective treatment for SRMs in this large cohort which included young, fit patients and underwent long-term follow-up. Recovery times were short, with low complication rates and favourable oncological outcomes in biopsy-proven T1 RCC <5 cm. ADVANCES IN KNOWLEDGE: The current study demonstrates a large, diverse MWA cohort (including T1b tumours) with high biopsy rate, minimal loss to follow-up, and long follow-up period facilitating assessment of long-term oncological outcomes in biopsy-proven RCC. The results support MWA as a safe, effective treatment for cT1a RCC that should be offered to patients as part of shared decision making.

Indexed as

Ablation TechniquesCarcinoma, Renal CellCatheter AblationKidney NeoplasmsMicrowavesRadiofrequency AblationAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm Recurrence, LocalTreatment Outcomekidney cancermicrowave ablationoncological outcomesrenal cell carcinomasmall renal massestumour ablation

Identifiers

PMID40839119
PMCPMC12810876

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.