Evidence map›Paper›PMID 40839059›Full record

Observational studyInternational urology and nephrology2026

Systemic inflammation is associated with reduced functional recovery in older inpatients with chronic kidney disease.

Keita Ohashi, Kentaro Iwata, Kanji Yamada, Yoshihiro Yoshimura, Atsuki Nozaki, Akio Yamamoto, Kumiko Ono, Takeshi Kitai, Akihiro Yoshimoto, Nobuo Kohara and 1 more

Abstract readObservational Study
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In one paragraph

Observational study in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Keita OhashiDepartment of Rehabilitation, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.ORCID http://orcid.org/0000-0003-2156-0878
Kentaro IwataDepartment of Rehabilitation, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan. iwaken@kcho.jp.
Kanji YamadaDepartment of Rehabilitation, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Yoshihiro YoshimuraCenter for Sarcopenia and Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto, Japan.
Atsuki NozakiDepartment of Rehabilitation, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Akio YamamotoDepartment of Public Health, Kobe University Graduate School of Health Sciences, Hyogo, Japan.
Kumiko OnoDepartment of Public Health, Kobe University Graduate School of Health Sciences, Hyogo, Japan.
Takeshi KitaiDepartment of Rehabilitation, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Akihiro YoshimotoDepartment of Nephrology, Kobe City Medical Center General Hospital, Hyogo, Japan.
Nobuo KoharaDepartment of Rehabilitation, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Akira IshikawaDepartment of Public Health, Kobe University Graduate School of Health Sciences, Hyogo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the association between systemic inflammation and activities of daily living (ADL) in older patients with chronic kidney disease (CKD) in the acute phase.

methodsThis observational, retrospective cohort study included patients with CKD aged 65 years and older with unscheduled admissions to the nephrology department between January 2019 and February 2022. Patients who underwent maintenance hemodialysis therapy; died during hospitalization; were treated in other departments; experienced serious events during hospitalization; or did not receive rehabilitation during hospitalization were excluded. Systemic inflammation was assessed by the modified Glasgow Prognostic Score (mGPS) on admission, and ADL was assessed by functional independence measure (FIM) at discharge.

resultsA total of 89 patients (median age, 80 years [interquartile range, 75-84 years]) were included in the analysis. An mGPS score of 0, 1, and 2 was assigned to 41 (46.1%), 15 (16.9%), and 33 (37.1%) patients, respectively. In multivariable analysis, the mGPS (SE = 2.16; β =  - 0.25; P = 0.001) was significantly associated with the FIM score at discharge. On the other hand, albumin (ρ = 0.093; 95% CI, - 0.12 to 0.30; P = 0.384) and CRP level (ρ =  - 0.176; 95% CI; - 0.37 to 0.03; P = 0.098) were not significantly correlated with the FIM score at discharge.

conclusionAmong older patients with CKD in the acute phase, systemic inflammation assessed using the mGPS may be useful for predicting ADL.

Indexed as

Activities of Daily LivingInflammationRecovery of FunctionRenal Insufficiency, ChronicAgedAged, 80 and overCohort StudiesFemaleHumansInpatientsMaleRetrospective StudiesActivities of daily livingChronic kidney diseaseFunctional independence measureModified glasgow prognostic scoreSystemic inflammation

Identifiers

PMID40839059

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.