ArticleInternational urology and nephrology2026
Beyond eGFR: critical appraisal of mannitol use in nephron- sparing surgery.
Article in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This letter evaluates the randomized trial by Cheriyan et al. regarding mannitol administration in laparoscopic nephron-sparing surgery. Major unaddressed limitations consist of arbitrary margin equivalences, dependence on per-protocol rather than intention-to-treat analysis, exclusion of functional renal imaging, and insufficient control of surgical confounders like warm ischemia duration. Moreover, the exclusion of individuals with chronic kidney disease limits generalizability. Drawing on previous PubMed-indexed studies, we emphasize these methodological flaws and promote the need for more stringent designs to elucidate mannitol's protective effects on the kidneys in contemporary nephron-sparing surgery.
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