Evidence map›Paper›PMID 40839032›Full record

ArticleJournal of neurology2025

Paramagnetic rim lesions are associated with choroid plexus inflammation and expansion over 5 years in people with multiple sclerosis.

Jack A Reeves, Ashley Tranquille, Alexander Bartnik, Maryam Mohebbi, Fahad Salman, Dejan Jakimovski, Ferdinand Schweser, Bianca Weinstock-Guttman, Michael G Dwyer, Eleonora Tavazzi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jack A ReevesDepartment of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 77 Goodell Street, Suite 440, Buffalo, NY, 14203, USA.ORCID http://orcid.org/0009-0002-4079-5664
Ashley TranquilleDepartment of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 77 Goodell Street, Suite 440, Buffalo, NY, 14203, USA.
Alexander BartnikDepartment of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 77 Goodell Street, Suite 440, Buffalo, NY, 14203, USA.ORCID http://orcid.org/0000-0001-9676-7377
Maryam MohebbiDepartment of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 77 Goodell Street, Suite 440, Buffalo, NY, 14203, USA.ORCID http://orcid.org/0009-0005-8429-3254
Fahad SalmanDepartment of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 77 Goodell Street, Suite 440, Buffalo, NY, 14203, USA.ORCID http://orcid.org/0009-0000-3873-2301
Dejan JakimovskiDepartment of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 77 Goodell Street, Suite 440, Buffalo, NY, 14203, USA.ORCID http://orcid.org/0000-0001-7114-4958
Ferdinand SchweserDepartment of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 77 Goodell Street, Suite 440, Buffalo, NY, 14203, USA.ORCID http://orcid.org/0000-0003-0399-9211
Bianca Weinstock-GuttmanJacobs Neurological Institute, Buffalo, NY, USA.ORCID http://orcid.org/0000-0001-6732-151X
Michael G DwyerDepartment of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 77 Goodell Street, Suite 440, Buffalo, NY, 14203, USA.ORCID http://orcid.org/0000-0003-4684-4658
Eleonora TavazziMultiple Sclerosis Centre, IRCCS Mondino Foundation, Pavia, Italy.ORCID http://orcid.org/0000-0003-2580-3646
Robert ZivadinovDepartment of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 77 Goodell Street, Suite 440, Buffalo, NY, 14203, USA.ORCID http://orcid.org/0000-0002-7799-1485
Niels BergslandDepartment of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 77 Goodell Street, Suite 440, Buffalo, NY, 14203, USA. npbergsland@bnac.net.ORCID http://orcid.org/0000-0002-7792-0433

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic active white matter inflammation is linked with multiple sclerosis (MS) clinical severity and is likely integral in MS progression. It has also been associated with choroid plexus (CP) inflammation in vivo, pointing to a potential pathophysiological link between the two phenomena. However, how these aspects of the disease co-evolve over time remains poorly understood nor has their relationship been specifically assessed in people with progressive MS (pwPMS).

methodsIn this retrospective analysis of a longitudinal study, 129 people with MS (pwMS; 86 people with relapsing remitting (pwRRMS) and 43 pwPMS) were imaged with 3 T MRI at baseline and after 5.4 years of follow-up. CP volume and CP pseudo-T2 (pT2) were calculated as measures reflecting CP inflammation in MS. Paramagnetic rim lesions (PRLs), a marker of chronic active white matter inflammation, were assessed at baseline for the whole cohort, and longitudinally in 96 pwMS with available data (66 pwRRMS, 32 pwPMS). Baseline and longitudinal associations between the CP and PRLs, including interactions with disease course, were assessed, adjusted for covariates including age and sex.

resultsPwMS with PRLs had significantly larger CP volume at baseline than pwMS without PRLs after correcting for age, sex, and disease duration (mean difference: 0.3 ± 1.2 mL; p = 0.042). Longitudinally, baseline PRL number was associated with increased CP volume in pwPMS (B = 0.22 mL/mL; p < 0.001), but not people with relapsing-remitting MS (B = - 0.01 mL/mL; p > 0.7).

conclusionIncreased CP volume is related to chronic white matter inflammation, particularly in pwPMS.

Indexed as

Choroid PlexusMultiple SclerosisMultiple Sclerosis, Chronic ProgressiveMultiple Sclerosis, Relapsing-RemittingWhite MatterAdultDisease ProgressionFemaleHumansInflammationLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesChoroid plexusChronic active lesionIron rim lesionMultiple sclerosisParamagnetic rim lesion

Identifiers

PMID40839032
PMCPMC12370838

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.