Evidence map›Paper›PMID 40839030›Full record

ReviewMolecular genetics and genomics : MGG2025

Role of Php domain and related enzymes in the enzymatic degradation of G-series nerve agents.

Divya Ramamoorthy, Rupa Iyer

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular genetics and genomics : MGG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Divya RamamoorthyInstitute for Biotechnology Research and Innovation, Tarleton State University, Division of Research, Innovation, and Economic Development (RIED), Stephenville, TX, USA. dramamoorthy@tarleton.edu.ORCID http://orcid.org/0009-0002-4164-1958
Rupa IyerDivision of Research, Innovation, and Economic Development (RIED), Tarleton State University, Stephenville, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The enzymatic breakdown of organophosphate (OP) nerve agents marks a pivotal advancement in both bioremediation and biodefense. This review explores the genetic diversity and evolutionary lineage of phosphotriesterase-related proteins across multiple species, with a particular focus on the Php domain, key to substrate recognition and hydrolysis. The study underscores the functional importance of Php-containing enzymes in neutralizing G-series nerve agents, highlighting their promise for environmental detoxification and defense applications. By laying the groundwork for enzyme-based OP degradation strategies, this work emphasizes the need for continued research and optimization of these enzymes and their microbial hosts to support sustainable remediation efforts.

Indexed as

Nerve AgentsPhosphoric Triester HydrolasesBiodegradation, EnvironmentalHydrolysisOrganophosphatesProtein DomainsNerve AgentsOrganophosphatesPhosphoric Triester HydrolasesBacterial strainsEnzyme degradationG-nerve agentsOrganophosphatesPesticides

Identifiers

PMID40839030

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.