Succinic acid enhances sedative activity of diazepam through GABAergic receptor modulation: Evidence from behavioral approach and computational insights.

Md Sakib Al Hasan, Yasin Emon, Mohammad Y Alshahrani, Imam Hossen Rakib, Emon Mia, Abida Sultana, Akayed Hasan, Muhammad Torequl Islam

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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5 · Who and what money

Authors and funding

8 authors.

Md Sakib Al HasanDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8100, Bangladesh. mdsakibalhasan192412@gmail.com.

Yasin EmonDepartment of Pharmacy, Islamic University, Kushtia, 7003, Bangladesh.

Mohammad Y AlshahraniCentral Labs, King Khalid University, P.O. Box 61413, Abha, 9088, Saudi Arabia.

Imam Hossen RakibDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8100, Bangladesh.

Emon MiaDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8100, Bangladesh.

Abida SultanaDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8100, Bangladesh.

Akayed HasanGraduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, PA, 15282, USA.

Muhammad Torequl IslamDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8100, Bangladesh. dmt.islam@gstu.edu.bd.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insomnia, a widespread neurological condition, is often managed with diazepam (DZP), a gamma-aminobutyric acid A (GABA

Indexed as

Behavior, AnimalDiazepamGABA-A Receptor AgonistsHypnotics and SedativesReceptors, GABA-ASuccinic AcidAnimalsDose-Response Relationship, DrugDrug SynergismLocomotionMaleMiceMolecular Docking SimulationMotor ActivitySleepDiazepamGABA-A Receptor AgonistsHypnotics and SedativesReceptors, GABA-ASuccinic AcidGABAA receptor modulationGABAergic pathwayPharmacokinetic profilingSuccinic acidSynergistic sedation

Identifiers

PMID40839005

DOI10.1016/j.drudis.2006.11.008

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.