ArticleJournal of medical virology2025
Dominance of DENV-1 and Flavivirus Serological Cross-Reactivity During the 2016 Dengue Outbreak in Vietnam.
Article in Journal of medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Severe dengue in hospitalized adults at two tertiary referral hospitals in northern Vietnam: clinical features and outcomes.Tropical medicine and health · 2026Article
- Seroprevalence of dengue in the general population of a Chinese southwestern border city: a community-based cross-sectional study.BMC infectious diseases · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV) pose a major health burden in Vietnam, where overlapping clinical features and serological cross-reactivity complicate accurate diagnosis and outbreak control. This study aimed to investigate circulating DENV serotypes and assess serological cross-reactivity with other flaviviruses during the 2016 dengue outbreak in central Vietnam. Aretrospective study was conducted on 146 hospitalized dengue patients during the 2016 outbreak in Binh Dinh province. Laboratory diagnosis included NS1antigen testing, ELISA (IgM/IgG), and real-time RT-PCR for DENV serotyping. IgM and IgG cross-reactivity with five flaviviruses, including DENV, ZIKV, JEV, West Nile virus (WNV), and tick-borne encephalitis virus (TBEV), and onealphavirus, chikungunya virus (CHIKV), was evaluated using ELISA. DENV-1 positive samples were further analysed by sequencing the capsid-premembrane (CprM) gene. DENV-1 was the predominant serotype (86%), with all sequenced strains clustering within genotype I. Secondary infections were more frequent (64%) than primary infections (36%) and were associated with a significantly higher median age (p = 0.003) and elevated hs-CRP levels (p = 0.029). Strong IgG cross-reactivity was observed among flaviviruses, particularly DENV, JEV, WNV, and TBEV (r > 0.85), while ZIKV and CHIKV showed low seropositivity. Incontrast, IgM responses demonstrated greater virus specificity. Ten PCR-negative cases showed broad serological reactivity, suggesting possible misdiagnosis or late-stage infection. Our findings reveal that DENV-1 genotype I was the predominant serotype during the 2016 outbreak in central Vietnam. Extensive IgG cross-reactivity among flaviviruses hinders serological diagnosis, highlighting the need for integrated molecular surveillance to ensure accurate outbreak response.
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