Evidence map›Paper›PMID 40838954›Full record

SynthesisAnnals of medicine2025

The risk of thyroid diseases in lichen sclerosus patients: a systematic review and meta-analysis.

Suvijak Untaaveesup, Piyawat Kantagowit, Nattawut Leelakanok, Wongsathorn Eiumtrakul, Petcharpa Chansate, Walaiorn Pratchyapruit, Chutintorn Sriphrapradang

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Suvijak UntaaveesupChao Khun Paiboon Hospital, Kanchanaburi, Thailand.ORCID 0009-0001-8954-7824
Piyawat KantagowitFaculty of Medicine, Chulalongkorn University, Bangkok, Thailand.ORCID 0000-0002-7890-8356
Nattawut LeelakanokDivision of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Burapha University, Chonburi, Thailand.ORCID 0000-0003-3533-4775
Wongsathorn EiumtrakulDepartment of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.ORCID 0009-0009-2728-8968
Petcharpa ChansateFaculty of Medicine, Thammasat University, Pathum Thani, Thailand.ORCID 0009-0003-3147-9659
Walaiorn PratchyapruitInstitute of Dermatology, Ministry of Public Health, Bangkok, Thailand.ORCID 0009-0002-1744-9309
Chutintorn SriphrapradangDepartment of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.ORCID 0000-0001-8294-8601

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectiveLichen sclerosus (LS) is a chronic inflammatory skin disease affecting both genital and extra-genital areas and is found predominantly in female patients. The relationship between LS and thyroid diseases remains unclear, with conflicting evidence reported in the literature. This systematic review and meta-analysis aimed to investigate the association between LS and thyroid diseases rigorously. MATERIALS AND

methodsWe conducted a comprehensive search using two electronic databases, MEDLINE and Embase, from inception to May 2024, to identify observational studies investigating the relationship between LS and thyroid diseases. A random-effects model was used to meta-analyse the pooled odds ratio with a 95% confidence interval (CI) from the included articles.

resultsA total of 14 observational articles encompassing 22,112,979 participants were included. Nine of these studies included only female participants. The analysis revealed that LS was significantly associated with an increased risk of autoimmune thyroid diseases, with an odds ratio of 2.38 (95% CI, 1.46-3.86;

conclusionsThis meta-analysis provided insight into thyroid diseases in patients with LS, revealing a significant association with an increased risk of autoimmune thyroid disease and hyperthyroidism. Further research is needed to clarify this association and enhance the comprehensive care of patients with LS.

Indexed as

Lichen Sclerosus et AtrophicusThyroid DiseasesFemaleGraves DiseaseHumansHyperthyroidismMaleObservational Studies as TopicOdds RatioRisk FactorsAutoimmune thyroiditisGraves’ diseaseHashimoto diseasehyperthyroidismhypothyroidismmeta-analysisthyroid diseasesvulvar Lichen sclerosus

Identifiers

PMID40838954
PMCPMC12372485

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.