Evidence map›Paper›PMID 40838899›Full record

ArticleJournal of surgical oncology2025

Factors Associated With Residual Positive Lymph Nodes With Targeted Axillary Lymph Node Dissection for Breast Cancer and Accuracy of Clipped Node Retrieval in Non-Mapping Patients.

Danielle E Brabender, Alexa Griffiths, Kaye A Lu, Katharine Armstrong, Maria E Nelson, Fumito Ito, Azadeh A Carr, Emily L Siegel, Stephen F Sener

Abstract read
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In one paragraph

Article in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Danielle E BrabenderDepartment of Surgery, Los Angeles General Medical Center, Los Angeles, California, USA.
Alexa GriffithsDepartment of Surgery, Los Angeles General Medical Center, Los Angeles, California, USA.
Kaye A LuDepartment of Surgery, Los Angeles General Medical Center, Los Angeles, California, USA.
Katharine ArmstrongDepartment of Surgery, Los Angeles General Medical Center, Los Angeles, California, USA.
Maria E NelsonDepartment of Surgery, Los Angeles General Medical Center, Los Angeles, California, USA.
Fumito ItoDepartment of Surgery, Los Angeles General Medical Center, Los Angeles, California, USA.
Azadeh A CarrDepartment of Surgery, Los Angeles General Medical Center, Los Angeles, California, USA.
Emily L SiegelDepartment of Surgery, Los Angeles General Medical Center, Los Angeles, California, USA.
Stephen F SenerDepartment of Surgery, Los Angeles General Medical Center, Los Angeles, California, USA.

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
NCI NIH HHS P30 CA014089The authors received no specific funding for this work.
6 · The paper itself

Abstract

backgroundThe current study aimed to determine whether results could justify whether axillary lymph node dissection (ALND) could be further de-escalated in selected patients having neoadjuvant chemotherapy (NAC).

methodsRetrospective analyses were performed for breast cancer patients treated with NAC from 2015 to 2023. Abnormal axillary nodes evaluated by pretreatment ultrasound had core biopsies with microclip placement. Patients assigned to ALND had histologically positive SLND (ypN+), were clinically node-positive (ycN+) post-NAC, did not map, or did not have a clipped node retrieved.

resultsThere were 274 predominantly Hispanic (78%) patients, the median age was 51 years, and the follow-up was 38.1 months. Of 198 pN+ patients, 120 were clinically node-negative (ycN0) post-NAC and had wire-directed (WD) SLND, whereas 78 were ycN+ and had planned ALND. Sixty percent of pN+ patients converted to ypN0 post-NAC. Fifty-eight percent of patients with ypN+ status had additional positive non-sentinel lymph nodes in the ALND specimen.

conclusionsALND was avoided in approximately half of patients who presented with axillary node metastases and became ycN0 post-NAC. Response to NAC correlated with node status at surgery. Patients who do not map may not need ALND if a pN+ clipped node is retrieved and converts to ypN0.

Indexed as

Breast NeoplasmsLymph Node ExcisionLymph NodesAdultAgedAxillaFemaleFollow-Up StudiesHumansLymphatic MetastasisMiddle AgedNeoadjuvant TherapyPrognosisRetrospective Studiesaxillary lymph node dissectionaxillary surgery de‐escalationneoadjuvant chemotherapysentinel lymph node dissectiontargeted axillary lymph node dissection

Identifiers

PMID40838899
PMCPMC12501913

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.