Evidence map›Paper›PMID 40838888›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

RyR1-mediated Ca

Takuya Kobayashi, Toshiko Yamazawa, Nagomi Kurebayashi, Masato Konishi, Jun Tanihata, Masami Sugihara, Yoshifumi Miki, Satoru Noguchi, Yukiko U Inoue, Takayoshi Inoue and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Pathogenic CaCommunications biology · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Takuya Kobayashi *Department of Pharmacology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.
Toshiko Yamazawa *Core Research Facilities, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo 105-8461, Japan.ORCID 0000-0002-4368-4794
Nagomi Kurebayashi *Department of Pharmacology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.ORCID 0000-0002-5005-9698
Masato KonishiDepartment of Pharmacology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.ORCID 0000-0003-3405-3357
Jun TanihataDepartment of Cell Physiology, The Jikei University School of Medicine, Tokyo 105-8461, Japan.ORCID 0000-0003-2539-2381
Masami SugiharaDepartment of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.ORCID 0000-0002-8014-4850
Yoshifumi MikiCore Research Facilities, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo 105-8461, Japan.ORCID 0009-0009-9567-4705
Satoru NoguchiDepartment of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan.ORCID 0000-0001-6165-3716
Yukiko U InoueDepartment of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan.ORCID 0000-0002-4105-9127
Takayoshi InoueDepartment of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan.ORCID 0000-0001-7155-2150
Takashi SakuraiDepartment of Pharmacology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.ORCID 0000-0001-9515-6574
Takashi MurayamaDepartment of Pharmacology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.ORCID 0000-0002-3845-2980

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 19K07105MEXT | Japan Society for the Promotion of Science (JSPS) 20K11368MEXT | Japan Society for the Promotion of Science (JSPS) 22H05055MEXT | Japan Society for the Promotion of Science (JSPS) 22K06652MEXT | Japan Society for the Promotion of Science (JSPS) 23K08684MEXT | Japan Society for the Promotion of Science (JSPS) 23K10692MEXT | Japan Society for the Promotion of Science (JSPS) 23K18453MEXT | Japan Society for the Promotion of Science (JSPS) 23K24067MEXT | Japan Society for the Promotion of Science (JSPS) 23K24778MEXT | Japan Society for the Promotion of Science (JSPS) 25K02443MEXT | Japan Society for the Promotion of Science (JSPS) 25K03053National Center of Neurology and Psychiatry (NCNP) 3-9National Center of Neurology and Psychiatry (NCNP) 5-6National Center of Neurology and Psychiatry (NCNP) 6-9
6 · The paper itself

Abstract

Type 1 ryanodine receptor (RyR1) is a Ca

Indexed as

CalciumExcitation Contraction CouplingMuscle, SkeletalRyanodine Receptor Calcium Release ChannelAnimalsCalcium SignalingMalignant HyperthermiaMiceMuscle ContractionMutationSarcoplasmic ReticulumCalciumryanodine receptor 1, mouseRyanodine Receptor Calcium Release Channelcalcium-induced calcium releasecalcium release channelexcitation–contraction couplingryanodine receptorskeletal muscle

Identifiers

PMID40838888
PMCPMC12403001

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.