SynthesisAge and ageing2025
Hospital admissions due to adverse drug reactions and adverse drug events in older adults: a systematic review.
Synthesis in Age and ageing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Epidemiology and characteristics of repeat adverse drug reactions and associated clinical outcomes in older adults: a systematic review and meta-analysis.European geriatric medicine · 2026Pooled it
- The association between age and medication-related hospital admission in adults: a systematic review and meta-analysis.International journal of clinical pharmacy · 2026Pooled it
- Hospital admissions due to adverse drug reactions and adverse drug events in older adults: a systematic review.Age and ageing · 2025Pooled it
- Diuretics in Cardiovascular Disease: For How Long and at What Dose?Journal of cardiovascular development and disease · 2026Review
- Potentially Inappropriate Prescription and Its Association with Index Hospitalization: A Multicenter, Cross-Sectional Study Using TIME Criteria.Drugs & aging · 2026Observational
- Characterising prescribing cascades in older community-dwelling adults attending general practice in The Netherlands: a retrospective cohort study.BMC primary care · 2026Article
- Cardiovascular adverse effects of common non-oncologic medications: from mechanisms to clinical management.European heart journal. Cardiovascular pharmacotherapy · 2026Review
- Associations between chronic disease profiles and self-reported adverse drug reactions in community-dwelling older adults: A cross-sectional study.Journal of Korean gerontological nursing · 2026Article
- Model-Informed Precision Dosing: Conceptual Framework for Therapeutic Drug Monitoring Integrating Machine Learning and Artificial Intelligence Within Population Health Informatics.Journal of personalized medicine · 2026Review
- Adverse Drug Reaction-Related Hospital Admissions and Adverse Drug Events and Their Association with Short- and Long-Term Health Outcomes in Older Adults.Geriatrics (Basel, Switzerland) · 2026Article
- Characteristics, preventability, management, and predictors of adverse drug reaction-related hospital admissions: a cross-sectional study in a Thai tertiary care hospital.Journal of pharmaceutical policy and practice · 2026Article
- Active monitoring vs. spontaneous reporting of antineoplastic drug-related adverse drug reactions: evidence from the Chinese hospital pharmacovigilance system.Frontiers in health services · 2025Article
- Clinical outcomes of adverse drug reaction-related hospital admissions in older adults with diabetes.Frontiers in pharmacology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdverse drug reactions (ADRs) and adverse drug events (ADEs) are consistently reported to cause up to 30% of hospital admissions in older adults, resulting in significant morbidity, mortality and an added health economic burden.This systematic review aimed to establish the frequency of ADRs and ADEs as a cause of hospitalisation in older adults.
methodsStandard databases and citations were searched from 2015 to 2025. Studies specifically assessing ADR and ADE prevalence and risk factors in older adults were included. The review was registered in PROSPERO (CRD42024613426) and quality was assessed using the Joanna Briggs Institute criteria with bias determined via ROBINS-E.
resultsNine studies underwent full evaluation. The reported prevalence of ADRs ranged from 3.3% to 23.1% and ADEs ranged from 11.75% to 18% as causes of hospitalisation. The median age of those included, in the respective studies, was between 77 and 86 years. Falls (19.4%-20.9%), delirium (7.3%-12.9%) and bleeding (8%-30.2%) were the most frequently encountered ADR/ADEs causing hospitalisation. Anti-thrombotics (11.5%-30.2%) diuretics (14.7%-30.2%) and renin-angiotensin-aldosterone system (RAAS) inhibitors (7.5%-8.9%) accounted for the highest proportion of ADR/ADE causative agents.
conclusionThis review has limitations stemming from the heterogeneity of the included studies and the exclusion of the grey literature. However, ADRs and ADEs remain a significant cause of hospital admissions in older patients. The possible preventability of these and their possible hospital admission avoidance highlights the critical need for further research into ADR/ADE risk prediction methods in addition to co-morbidity and medication optimisation for older adults.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.