Evidence map›Paper›PMID 40838650›Full record

ArticleLaboratory animals2025

Giving less power to statistical power.

Megan D Higgs, Valentin Amrhein

Abstract read
In one paragraph

Article in Laboratory animals, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Megan D HiggsCritical Inference LLC, Bozeman, USA.
Valentin AmrheinDepartment of Environmental Sciences, University of Basel, Switzerland.ORCID 0000-0001-5173-4571

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Researchers often need to justify their choice of sample size, particularly in fields such as animal and clinical research, where there are obvious ethical concerns about relying on too many or too few study subjects. The common approach is still to depend on statistical power calculations, typically carried out using simple formulas and default values. Over-reliance on power, however, not only carries the baggage of statistical hypothesis tests that have been criticized for decades, but also blocks an opportunity to strengthen the research in the design phase by learning about challenges in interpretation before the study is carried out. We recommend constructing a 'quantitative backdrop' in the planning stage of a study, which means explicitly connecting ranges of possible research outcomes to their expected real-life implications. Such a backdrop can facilitate

Indexed as

Research DesignAnimalsData Interpretation, StatisticalSample Sizealpha levelCompatibility intervalconfidence intervaldichotomaniaprecisionstatistical significance

Identifiers

PMID40838650
PMCPMC12913686

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.