Evidence map›Paper›PMID 40838563›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2025

High-Speed Quantitative Nanomechanical Mapping by Photothermal Off-Resonance Atomic Force Microscopy.

Hans Gunstheimer, Gotthold Fläschner, Jonathan D Adams, Hendrik Hölscher, Bart W Hoogenboom

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hans GunstheimerInstitute of Microstructure Technology, Karlsruhe Institute of Technology (KIT), P.O. Box 3640, 76021, Karlsruhe, Germany.
Gotthold FläschnerNanosurf AG, Gräubernstrasse 12/14, Liestal, 4410, Switzerland.
Jonathan D AdamsNanosurf AG, Gräubernstrasse 12/14, Liestal, 4410, Switzerland.
Hendrik HölscherInstitute of Microstructure Technology, Karlsruhe Institute of Technology (KIT), P.O. Box 3640, 76021, Karlsruhe, Germany.ORCID https://orcid.org/0000-0002-1033-1669
Bart W HoogenboomNanosurf AG, Gräubernstrasse 12/14, Liestal, 4410, Switzerland.ORCID https://orcid.org/0000-0002-8882-4324

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atomic force microscopy (AFM) is widely used to measure surface topography of solid, soft, and living matter at the nanoscale. Moreover, by mapping forces as a function of distance to the surface, AFM can provide a wealth of information beyond topography, with nanomechanical properties as a prime example. Here, a method based on photothermal off-resonance tapping (PORT) is presented to increase the speed of such force spectroscopy measurements by at least an order of magnitude, thereby enabling high-throughput, quantitative nanomechanical mapping of a wide range of materials. Specifically, photothermal actuation is used to modulate the position of the AFM probe at frequencies that far exceed those possible with traditional actuation by piezo-driven z scanners. Understanding and accounting for the microscale thermal and mechanical behavior of the AFM probe, the study determines the resulting probe position at sufficient accuracy to allow rapid and quantitative nanomechanical examination of polymeric and metallic materials.

Indexed as

atomic force microscopyforce spectroscopynanomechanical characterizationoff‐resonance tappingphotothermal excitation

Identifiers

PMID40838563
PMCPMC12508714

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.