ArticleAdvanced healthcare materials2026
An Innovative "Tooth-On-Chip" Microfluidic Device Emulating the Structure and Physiology of the Dental Pulp Tissue.
Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- A multi-modal profiling workflow of transcriptomics and biomineralization demonstrated on a tooth-on-chip model.MethodsX · 2026Article
- A review of the wide applications of microfluidic devices in peri-implantitis, periodontitis, and endodontics.Odontology · 2026Review
- Inflammation-Regeneration Axis of Dental Pulp Stem Cells: Wnt/NF-κB Crosstalk.International endodontic journal · 2026Review
- Mechanobiology of orofacial tissues: principles, mechanisms, and therapeutic applications.International journal of oral science · 2026Review
- Organ-on-chip (OoC) and nano-biomaterials: next generation of precision oral and dental healthcare research.Journal of nanobiotechnology · 2026Review
- An Innovative "Tooth-On-Chip" Microfluidic Device Emulating the Structure and Physiology of the Dental Pulp Tissue.Advanced healthcare materials · 2026Article
- The dental pulp as a high-resolution model for neurovascular niche biology.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The dental pulp is a highly vascularized and innervated connective tissue composed of various cell types, including fibroblasts, odontoblasts, mesenchymal stem cells, neuronal, and endothelial cells. The interplay between these diverse cell populations is pivotal for dental pulp tissue homeostasis and regeneration after carious infections and traumatic tooth lesions. Despite the great clinical need, comprehensive in vitro models that accurately recapitulate the complexity of the dental pulp are still missing, hampering the development of novel, faster, and more effective therapies. In this study, an innovative "tooth-on-chip" microfluidic device is presented to emulate the composition and three-dimensional structure of the dental pulp tissue in vitro. Co-culture of human dental pulp stem cells, odontoblast-like cells, endothelial cells, and trigeminal neurones in this miniaturized system successfully reproduced the structural organization and physiology of the dental pulp. The microfluidic device integrated various compartments that allowed the generation of complex vascular and neuronal networks, the formation of stem cell perivascular niches, and the formation of an odontoblast/dentine interface. The "tooth-on-chip" device represents a conceptual leap in replicating dental pulp physiology in vitro, offering a state-of-the-art platform to study dental pulp physiology and pathology and serving as a benchmark to create more advanced tooth simulation systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.