Evidence map›Paper›PMID 40838490›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society

Burden of Seasonal Human Coronavirus Infections in Hematopoietic Cell Transplant Recipients.

Fareed Khawaja, Terri Lynn Shigle, Layale Yaghi, May Daher, Jeremy L Ramdial, Ella Ariza-Heredia, Ying Jiang, Roy F Chemaly

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Burden of Seasonal Human Coronavirus Infections in Hematopoietic Cell Transplant Recipients.Transplant infectious disease : an official journal of the Transplantation Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fareed KhawajaDepartment of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Terri Lynn ShigleDepartment of Pharmacy Clinical Programs, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Layale YaghiDepartment of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
May DaherDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Jeremy L RamdialDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Ella Ariza-HerediaDepartment of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Ying JiangDepartment of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Roy F ChemalyDepartment of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
Cancer Center Support GrantNCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

backgroundCommunity respiratory viruses, such as seasonal human coronavirus (HCoV), commonly infect hematopoietic cell transplant (HCT) recipients. Recognizing the risk factors and outcomes of HCoV infections in HCT recipients is essential for the future development of potentially lifesaving therapeutics.

methodsWe performed a retrospective review of all HCoV-infected HCT recipients from September 1, 2015 to August 31, 2017, at our institution. Patients were classified with upper respiratory tract infection (URI) or lower respiratory infection (LRI) based on predefined definitions for respiratory viral infections in HCT recipients. Patient data were collected to identify risk factors for HCoV LRI, and to calculate an immunodeficiency scoring index (ISI). Univariate and multivariate analysis were performed to identify risk factors for LRI.

resultsWe identified 164 episodes in 138 HCT recipients (129 URI and 35 LRI) during the study period with an incidence of HCoV of 9%. Overall, 30-day mortality was 17% and 0%, among patients with HCoV LRI or URI, respectively. On multivariate analysis, low-albumin, coinfection with multiple respiratory viruses, and an ISI ≥ 5 were independent predictors of LRI and the latter was associated with increased risk of hospital admission, ICU admission, mechanical ventilation, and 30-day mortality.

conclusionsWe identified unique characteristics that were associated with HCoV LRI in HCT recipients. An ISI ≥ 5 predicted HCoV LRI in HCT recipients.

Indexed as

Coronavirus InfectionsHematopoietic Stem Cell TransplantationRespiratory Tract InfectionsAdultAgedCoinfectionFemaleHospitalizationHumansIncidenceMaleMiddle AgedRetrospective StudiesRisk FactorsSeasonsTransplant Recipientscoronavirushematopoietic cell transplantoutcomestem cell transplant

Identifiers

PMID40838490
PMCPMC12519910

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.