ReviewAndrology2026
Gender-affirming hormone therapy: Effect on semen quality and use of fertility preservation.
Review in Andrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Gender-affirming hormone therapy: Effect on semen quality and use of fertility preservation.Andrology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Fertility preservation (FP) is a fundamental part of gender care. Gender-affirming hormone therapy (GAHT) involves the use of drugs that could be potential risk factors for fertility. Therefore, FP is recommended before beginning the gender-affirmation process. This narrative review aims to assess several aspects, mainly concerning the assigned male at birth (AMAB) population. The purpose of this review is to provide an overview of the effects of GAHT on testicular morphology and seminal quality, the use of semen cryopreservation, the desire for parenthood among transgender people, the factors influencing the decision to use fertility preservation (FP) and suggestions for improving clinical practice. A literature search within PubMed was conducted and the results deal with issues such as changes in testicular morphology and semen quality, FP utilization, barriers to treatment, current clinical practice models, and suggestions for improving transgender adolescents access to FP. The results showed that GAHT can have a negative effect on fertility in transgender AMAB subjects. It is therefore recommended to carry out FP before starting such treatment. However, there is low percentage of utilization to FP among transgender adolescents. In deciding whether to pursue FP, they consider many factors: future parenting desires, individual experiences of gender dysphoria, family values around biological parenting, financial considerations, and the availability of fertility information. A discrepancy emerged between the rate of desire to become a parent and the actual rate of FP utilization. The reasons are various, such as cost, and concern in delaying the initiation of treatment. Suggestions for improving clinical practice are also provided from this literature search.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.