ArticleJournal of cosmetic dermatology2025
Comprehensive Evaluation of the Safety and Efficacy of MOSY PHYCOLLREPAIR: A Novel Fermented Black Bee Honey-Derived Cosmetic Ingredient.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Guang Chenpi Extract as a Multifunctional Phytotherapeutic: Enhanced Effects with Ergothioneine and Polydeoxyribonucleotide on Redox Homeostasis and Tissue Resilience.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Comprehensive Evaluation of the Safety and Efficacy of MOSY PHYCOLLREPAIR: A Novel Fermented Black Bee Honey-Derived Cosmetic Ingredient.Journal of cosmetic dermatology · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMOSY PHYCOLLREPAIR is an innovative cosmetic ingredient extracted from fermented blank bee honey, specifically engineered for dermatological applications.
objectiveThis study seeks to thoroughly evaluate the safety and diverse efficacy profiles of MOSY PHYCOLLREPAIR within cosmetic formulations.
methodsThe safety of MOSY PHYCOLLREPAIR was determined through zebrafish embryo developmental toxicity assays. Its dermatological benefits were assessed via a comprehensive series of in vivo zebrafish embryo tests, encompassing antioxidation, anti-inflammation, modulation of type I collagen, elastin, and sirt1 gene expression, wound healing, skin barrier integrity, UV protection, and skin whitening.
resultsMOSY PHYCOLLREPAIR demonstrated non-toxicity to zebrafish embryos at concentrations up to 3.08 mg/mL. It showed significant efficacy across multiple parameters: 29.10%-62.48% anti-ROS activity, 11.08%-27.84% anti-inflammatory effect, 60.25%-295.67% ATP-enhancing efficacy, and 6.52%-17.80% melanin inhibition at concentrations ranging from 25 to 500 μg/mL. It also upregulated the expression of type I collagen genes col1a1 by 87.67% to 281.61%, col1a2 by 54.08% to 165.14%, astin gene elna by 55.81% to 174.03%, and sirt1 gene by 60.25%-295.67%. Additionally, MOSY PHYCOLLREPAIR enhanced wound healing by 8.33%-19.44% at concentrations between 5 and 100 μg/mL, provided 39.36% to 70.26% skin barrier protection against chemical peel at 100 to 500 μg/mL, and offered 20.15%-68.45% UVB irradiation protection at 200 to 2000 μg/mL.
conclusionThis study marks the first application of fermented blank bee honey as an active cosmetic ingredient. The findings conclusively establish MOSY PHYCOLLREPAIR as a safe and highly effective cosmetic component, delivering a broad range of anti-aging and skin health benefits.
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Registered trials
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