ArticleOpen forum infectious diseases2025
Cytomegalovirus Reactivation in Critically Ill Patients With Acute Necrotizing Pancreatitis.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05898048 (Cytomegalovirus Reactivation in Acute Necrotizing Pancreatitis), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Cytomegalovirus Reactivation in Acute Necrotizing Pancreatitis
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In recent years, cytomegalovirus (CMV) reactivation has been recognized during the critical illness of apparently nonimmunosuppressed patients, impacting their clinical outcomes. However, no study is available on CMV reactivation among acute necrotizing pancreatitis (ANP) patients. Methods: In this prospective cohort study of adult ANP patients requiring intensive care unit admission with apparently immunocompetent and CMV seropositive status, clinical samples were analyzed on a weekly basis for CMV copies. CMV reactivation was considered when the viral load exceeded 1000 copies/mL in plasma. Results: During the study period, 284 samples (plasma 149, drain content 125, and necrotic tissue 10) were analyzed from 41 ANP patients. At enrollment, the median (interquartile range) age was 35 (25-40) years, SOFA score was 7 (6-9), and computed tomography severity index of pancreatitis was 10 (6-10). CMV reactivation was detected in the plasma of 13 patients (31.7%) with an average viral load (range) of 3900 (1500-5600) copies/mL. These patients had higher rates of intra-abdominal (92%) and bloodstream infections (77%). Among these individuals, the maximum CMV in plasma was 8180 (7500-38 500) copies/mL and 3200 (2250-4075) copies/mL ( Conclusions: Up to one-third of ANP patients experienced CMV reactivation. Higher and persistent CMV copies in the clinical samples were associated with poorer clinical outcomes. ClinicalTrialsgov Identifier: NCT05898048.
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