Evidence map›Paper›PMID 40838215›Full record

ArticleMaterials today. Bio2025

Microfluidics-enabled polydopamine-coated selenium nanoparticles in hyaluronic hydrogel microspheres for targeted antioxidant and immunomodulatory therapy of ulcerative colitis.

Ying Fang, Hongwei Yu, Xiaochen Feng, Haike Xia, Yunze Xu, Ranjith Kumar Kankala, Aizheng Chen, Chaoping Fu

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Ying FangCollege of Materials Science and Engineering, Huaqiao University, Xiamen, Fujian, 361021, China.
Hongwei YuCollege of Materials Science and Engineering, Huaqiao University, Xiamen, Fujian, 361021, China.
Xiaochen FengCollege of Materials Science and Engineering, Huaqiao University, Xiamen, Fujian, 361021, China.
Haike XiaCollege of Materials Science and Engineering, Huaqiao University, Xiamen, Fujian, 361021, China.
Yunze XuCollege of Materials Science and Engineering, Huaqiao University, Xiamen, Fujian, 361021, China.
Ranjith Kumar KankalaCollege of Materials Science and Engineering, Huaqiao University, Xiamen, Fujian, 361021, China.
Aizheng ChenCollege of Materials Science and Engineering, Huaqiao University, Xiamen, Fujian, 361021, China.
Chaoping FuCollege of Materials Science and Engineering, Huaqiao University, Xiamen, Fujian, 361021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ulcerative colitis (UC) is manifested by excessive oxidative stress and immune dysregulation in the colonic microenvironment. To address these pathological features, we developed a microfluidics-engineered oral delivery system comprising methacrylated hyaluronic acid (HAMA) hydrogel microspheres encapsulating polydopamine-coated selenium nanoparticles (CS-Se@PDA). The uniform microspheres featured a microfluidics-enabled structure that enabled stable CS-Se@PDA nanoparticles anchoring via electrostatic and covalent interactions. The PDA coating enhanced the stability, mucosal adhesion, and scavenging of reactive oxygen species (ROS) of the nanoparticles. At the same time, the HAMA shell provided pH-responsive protection and CD44-mediated targeting to inflamed colonic tissues.

Indexed as

Microfluidics-enabled hydrogel microspheresOral drug deliveryPolydopamineSelenium nanoparticlesUlcerative colitis

Identifiers

PMID40838215
PMCPMC12362089

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.