ArticleFrontiers in endocrinology2025
Management of LH/FSH deficiency among assisted reproduction specialists in Spain: a Delphi consensus.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Recombinant LH supplementation during ovarian stimulation modulates early embryo morphokinetics without affecting IVF outcomes in normal responders: a retrospective time-lapse study.Journal of assisted reproduction and genetics · 2026Article
- Empty Follicle Syndrome: Current Therapeutic Approaches and the Role of Triggering Agents in Assisted Reproductive Technology.Medical sciences (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) deficiency can decrease women fertility, due to compromised gametogenesis and steroidogenesis. Several factors, like age, LH/FSH and their receptor polymorphisms, and gonadotrophin-releasing hormone analogue protocols; might result in a hypo-response to ovarian stimulation. The International Committee for Monitoring Assisted Reproduction Technologies (ICMART) highlighted the importance of addressing LH/FSH deficiency for a successful outcome. The aim was to understand if consensus exists on LH/FSH deficiency management among specialists in assisted reproduction based on the latest available evidence. Methods: An online, two-round Delphi consensus questionnaire was conducted from December 2021 to January 2022. The questionnaire comprised 21 statements concerning the action of LH/FSH in disrupted physiological conditions, clinical presentation of LH/FSH deficiency and its importance in assisted reproduction. A 70% agreement threshold was established for each statement. Results: Responses from 45 and 42 assisted reproduction Spanish specialists were gathered in the first and second rounds. Consensus was reached in almost half (10/21) of the statements. Participants mostly agreed on the relevance of LH/FSH deficiency due to a reduction of the action and production of gonadotropins, the importance of the effect of different glycosylation variants and age in LH/FSH action and of estradiol (E Conclusions: It is important to consider the diverse factors that can lead to LH/FSH deficiency in order to optimize its management and improve reproductive outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.