Evidence map›Paper›PMID 40838186›Full record

ArticleCochrane evidence synthesis and methods2025

Lifecycles of Cochrane Systematic Reviews (2003-2024): A Bibliographic Study.

Shiyin Li, Chong Wu, Zichen Zhang, Mengli Xiao, Mohammad Hassan Murad, Lifeng Lin

Abstract read
In one paragraph

Article in Cochrane evidence synthesis and methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shiyin LiDepartment of Epidemiology and Biostatistics University of Arizona Tucson AZ USA.
Chong WuDepartment of Biostatistics The University of Texas MD Anderson Cancer Center Houston TX USA.
Zichen ZhangDepartment of Biostatistics The University of Texas MD Anderson Cancer Center Houston TX USA.
Mengli XiaoDepartment of Biostatistics and Informatics University of Colorado Anschutz Medical Campus Aurora CO USA.
Mohammad Hassan MuradEvidence-Based Practice Center Mayo Clinic Rochester MN USA.ORCID https://orcid.org/0000-0001-5502-5975
Lifeng LinDepartment of Epidemiology and Biostatistics University of Arizona Tucson AZ USA.ORCID https://orcid.org/0000-0002-3562-9816

Funding

Statistical Methods and Software for Multivariate Meta-analysisR01LM012982 · NLM · UNIVERSITY OF MINNESOTA · PI LIN, LIFENG, SIEGEL, LIANNE · 2019 to 2022
$1.3M
Advanced Methods and Software for Trial Sequential Analysis in Living Systematic ReviewsR21LM014533 · NLM · UNIVERSITY OF ARIZONA · PI LIN, LIFENG · 2024 to 2025
$364k
Innovative Data Integration Models for Handling Evidence Inconsistency in AD/ADRD ResearchR03AG093555 · NIA · UNIVERSITY OF ARIZONA · PI LIN, LIFENG · 2025 to 2025
$301k
Joint modeling of continuous and binary data in meta-analysisR03MH128727 · NIMH · UNIVERSITY OF ARIZONA · PI LIN, LIFENG · 2022 to 2023
$146k
NIA NIH HHS R03 AG093555NIMH NIH HHS R03 MH128727NLM NIH HHS R01 LM012982NLM NIH HHS R21 LM014533
6 · The paper itself

Abstract

Background and Objectives: The relevance of Cochrane systematic reviews depends on timely completion and updates. This study aimed to empirically assess the lifecycles of Cochrane reviews published from 2003 to 2024, including transitions from protocol to review, update patterns, and withdrawals. Methods: We extracted data from Cochrane Library publications between 2003 and 2024. Each review topic was identified using a unique six-digit DOI-based ID. We recorded protocol publication, review publication, updates, and withdrawals (i.e., removed from the Cochrane Library for editorial or procedural reasons), calculating time intervals between stages and conducting subgroup analyses by review type. Results: Of 8137 protocols, 71.9% progressed to reviews (median 25.7 months), 2.4% were updated during the protocol stage, and 10.0% were withdrawn. Among 8477 reviews, 64.3% were never updated by the time of our analysis; for those updated at least once, the median interval between updates was 57.2 months. Withdrawal occurred in 2.5% of reviews (median 67.6 months post-publication). Subgroup analyses showed variation across review types; diagnostic and qualitative reviews tended to have longer protocol-to-review times than other types of reviews. Conclusions: Cochrane reviews show long development and update intervals, with variation by review type. Greater use of automation and targeted support may improve review efficiency and timeliness.

Indexed as

Cochrane systematic reviewslifecyclemeta‐researchreview updatewithdrawal

Identifiers

PMID40838186
PMCPMC12362767

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.