Evidence map›Paper›PMID 40838121›Full record

ArticlemicroPublication biology2025

PITX2 is enriched in highly adipogenic brown preadipocytes.

Manal Al Dow, Charles Colas, Blandine Secco, Alona Kolnohuz, Nolwenn Samson, Audrey Poirier, Romain Villot, Laurence Belley, Bochra Chadel, Laura Tribouillard and 5 more

Abstract read
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In one paragraph

Article in microPublication biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Manal Al DowCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ).
Charles ColasCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ).
Blandine SeccoCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ).
Alona KolnohuzCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ).
Nolwenn SamsonCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ).
Audrey PoirierCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ).
Romain VillotCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ).
Laurence BelleyCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ).
Bochra ChadelCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ).
Laura TribouillardCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ).
Alyson DufourCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ).
Mathilde MouchiroudCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ).
Yves GélinasCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ).
Mathieu C MorissetteCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ).
Mathieu LaplanteCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brown adipose tissue (BAT) serves as a key heat-producing organ required to maintain body temperature and homeothermy in mammals. BAT recruitment and activation deeply impacts metabolic homeostasis in both mice and humans. Despite recent advances, the nature of the factors that functionally characterize brown adipose precursors are still incompletely characterized. Here, we provide a comprehensive transcriptomic analysis of brown preadipocyte cell lines with low or high adipogenic potential. Using this resource, we report the identification of paired-like homeodomain 2 (PITX2) as a transcription factor highly enriched in committed brown preadipocytes.

Identifiers

PMID40838121
PMCPMC12364533

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.