ArticleFrontiers in plant science2025
DNA methylation valley as a distinguishing feature occurs in root-specific expressed nicotine-related genes in
Article in Frontiers in plant science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Transcriptional Activation of NaNAC72 Suppresses Nicotine Biosynthesis in DNA Methyltransferase NaDRM2-like2 Mutants of Nicotiana attenuata.Plant biotechnology journal · 2026Article
- Auxin-Induced Nicotine Inhibition Is Mediated by NaARF5 Through the Suppression of NaERF1-Like Expression and Interaction With NaERF1-Like in Nicotiana attenuata.Plant biotechnology journal · 2026Article
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Authors and funding
3 authors.
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Abstract
Introduction: Nicotine, the main defense alkaloid of Results and discussion: We found that most of the nicotine-related genes were exclusively and highly expressed in the root, while their DNA methylation patterns were very similar in both tissues. Interestingly, these genes with root-specific expression share a prominent DNA methylation valley (DMV) as a distinguishing feature. Further analysis revealed that 37.4% of the root-preferentially expressed genes were DMV genes, suggesting that root-specific expressed genes, including these nicotine-related genes, were strongly associated with DMV. Our results revealed that having a DMV is a common feature of most nicotine-related genes that are expressed only in the root. Thus, our results provide new insights into the regulation of alkaloid biosynthesis by epigenetic modification.
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