Evidence map›Paper›PMID 40838061›Full record

ArticleFrontiers in drug delivery2023

Polyethylene Glycol-grafted poly alpha-lipoic acid-dexamethasone nanoparticles for osteoarthritis.

Yuanqiang Cheng, Zheng Jing, Yan Xu, Lihui Sun, Dongbo Li, Jianguo Liu, Dongsong Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in drug delivery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuanqiang ChengDepartment of Orthopaedics, First Affiliated Hospital of Jilin University, Changchun, China.
Zheng JingDepartment of Orthopaedics, First Affiliated Hospital of Jilin University, Changchun, China.
Yan XuDepartment of Orthopaedics, First Affiliated Hospital of Jilin University, Changchun, China.
Lihui SunDepartment of Orthopaedics, First Affiliated Hospital of Jilin University, Changchun, China.
Dongbo LiDepartment of Orthopaedics, First Affiliated Hospital of Jilin University, Changchun, China.
Jianguo LiuDepartment of Orthopaedics, First Affiliated Hospital of Jilin University, Changchun, China.
Dongsong LiDepartment of Orthopaedics, First Affiliated Hospital of Jilin University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is a chronic inflammatory disease that causes synovial hyperplasia, cartilage destruction, and the formation of bone spurs. Macrophages play an indispensable role in the pathogenesis of OA by producing proinflammatory cytokines. To achieve the effect of arthritis, hormones can effectively inhibit the progression of inflammation by inhibiting the secretion of inflammatory cytokines by macrophages in traditional therapy. However, the drug is quickly cleared from the joint space, and the high injection site infection rate and low local drug concentration make the clinical efficacy of corticosteroids greatly reduced. We described the design and preparation of Polyethylene Glycol-grafted Poly Alpha-lipoic Acid-dexamethasone Nanoparticles (NP

Indexed as

dexamethasoneintraarticular injectionintraarticular injection of knee jointnanoparticlesosteoarthritispolylipoic acid

Identifiers

PMID40838061
PMCPMC12363283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.