Evidence map›Paper›PMID 40838056›Full record

ArticleFrontiers in drug delivery2023

Molecular distribution in intradermal injection for transfer and delivery of therapeutics.

Emran O Lallow, Kishankumar J Busha, Sarah H Park, Maria Atzampou, Nandita C Jhumur, Yasir Demiryurek, Christine C Roberts, Jerry W Shan, Jeffrey D Zahn, David I Shreiber and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in drug delivery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Emran O LallowDepartment of Mechanical and Aerospace Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.
Kishankumar J BushaDepartment of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.
Sarah H ParkDepartment of Materials Science and Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.
Maria AtzampouDepartment of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.
Nandita C JhumurDepartment of Mechanical and Aerospace Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.
Yasir DemiryurekDepartment of Mechanical Engineering, Temple University, Philadelphia, PA, United States.
Christine C RobertsGeneOne Life Science Inc., Seoul, South Korea.
Jerry W ShanDepartment of Mechanical and Aerospace Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.
Jeffrey D ZahnDepartment of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.
David I ShreiberDepartment of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.
Young K ParkGeneOne Life Science Inc., Seoul, South Korea.
Jonathan P SingerDepartment of Mechanical and Aerospace Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.
Joel N MaslowGeneOne Life Science Inc., Seoul, South Korea.
Hao LinDepartment of Mechanical and Aerospace Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intradermal (ID) injection is a technique widely used in laboratorial and clinical applications. The boundary of the dome-like bleb formed during injection is assumed to represent the lateral extent of the injected material. This work systematically characterizes cargo molecule distribution (puddle) as a function of injection volume and molecular/particle size in rat skin post ID injection. In general, results indicate that the puddle forms a subdomain laterally contained within the bleb, with an area inversely correlating to the molecular size of the injected material. For 50 μL and 100 µL injections, the average area of the bleb was 40.97 ± 6.30 mm

Indexed as

DNA-based vaccinesintradermal injectionmolecular deliverymolecular distributiontransfection

Identifiers

PMID40838056
PMCPMC12363334

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.