ArticleAsian journal of transfusion science
Exploring the influence of donor physiognomic factors on packed red cell unit quality: A retrospective analysis from a tertiary care transfusion center.
Article in Asian journal of transfusion science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDonor physiognomic characteristics play a critical role in determining the quality of packed red cell units (PRBCs), which directly impacts transfusion outcomes. This retrospective study aimed to evaluate the influence of donor physiognomic factors on PRBC quality at a tertiary care transfusion center.
methodsA retrospective analysis was conducted on 250 randomly selected blood donors from January 2015 to August 2018. Donor age, gender, weight, and predonation hemoglobin (PHB) levels were assessed, along with PRBC parameters including volume (350 ml vs. 450 ml), processing method, PRBC age, and percent hemolysis during storage. Subsequent evaluations included hematocrit, per unit total hemoglobin (UTHB), and red cell mass.
resultsThe mean weight among donors aged 18-28 years was 69.8 kg, compared to 74.46 kg in higher age groups. Lower PHB levels (12.5-13.0 g/dL) were associated with decreased UTHB. PRBCs prepared using the buffy coat method exhibited lower mean UTHB compared to other methods. A significant correlation (
conclusionsDonor PHB significantly influences the quality of PRBCs prepared, with lower PHB levels correlating with decreased UTHB. PRBCs prepared using the buffy coat method showed inferior UTHB, and older PRBC units displayed higher red cell hemolysis. However, donor gender, age, and weight did not significantly affect PRBC quality in this study. Larger sample sizes are necessary to confirm these findings. These results highlight the importance of donor screening and selection to optimize PRBC quality and enhance transfusion therapy outcomes.
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