Evidence map›Paper›PMID 40837969›Full record

Article3 Biotech2025

Mechanistic understanding of Wiskott-Aldrich syndrome protein (WASp)-mediated epigenetic regulation of T helper cell differentiation in acute leukemia.

R Pradeep, Sudeshna Rakshit, Geetha Shanmugam, Amit Choudhary, Ramya Ramesh, Jaikumar G Ramamoorthy, Reena Gulati, Deepak Amalnath, Prabhu Manivannan, Smita Kayal and 2 more

Abstract read
In one paragraph

Article in 3 Biotech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

R PradeepDepartment of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Katangulathur, Chennai, Tamil Nadu 603203 India.ORCID 0000-0003-0619-2309
Sudeshna RakshitDepartment of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Katangulathur, Chennai, Tamil Nadu 603203 India.ORCID 0000-0002-7496-3155
Geetha ShanmugamDepartment of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Katangulathur, Chennai, Tamil Nadu 603203 India.ORCID 0000-0003-3035-6190
Amit ChoudharyDepartment of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006 India.ORCID 0009-0009-8200-5676
Ramya RameshDepartment of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006 India.ORCID 0000-0002-3731-8181
Jaikumar G RamamoorthyDepartment of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006 India.ORCID 0000-0002-0446-7260
Reena GulatiDepartment of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006 India.ORCID 0000-0002-6158-077X
Deepak AmalnathDepartment of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006 India.ORCID 0000-0002-3286-0107
Prabhu ManivannanDepartment of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006 India.ORCID 0000-0001-8247-3343
Smita KayalDepartment of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006 India.ORCID 0000-0001-7275-7377
Saptak BanerjeeDepartment of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, West Bengal 700026 India.ORCID 0000-0001-9211-2074
Koustav SarkarDepartment of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Katangulathur, Chennai, Tamil Nadu 603203 India.ORCID 0000-0002-0696-6688

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wiskott-Aldrich syndrome protein (WASp) is exclusively expressed in hematopoietic cells, yet its role in leukemia remains poorly defined. This study investigates the epigenetic regulation of key immune genes by T helper (T Supplementary Information: The online version contains supplementary material available at 10.1007/s13205-025-04474-4.

Indexed as

Acute leukemiaCRISPR–Cas9Epigenetic regulationMethylationT helper (TH) cellWiskott–Aldrich syndrome protein

Identifiers

PMID40837969
PMCPMC12361005

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.