ArticleCureus2025
Symptom Burden and Intervention Outcomes in Idiopathic Normal Pressure Hydrocephalus: A Multicenter Retrospective Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- National trends in hydrocephalus mortality in the United States, 1999-2024: a serial cross-sectional (ecological) trend analysis.Frontiers in public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionNormal pressure hydrocephalus (NPH) is a potentially reversible cause of dementia, characterized by a clinical triad of gait disturbance, urinary incontinence, and cognitive decline. Despite suggestive radiologic findings, many patients remain untreated. This study aimed to determine the clinical correlation between radiographic findings of NPH and clinical symptoms. It also investigated whether the number of NPH symptoms predicts the likelihood of intervention and clinical improvement (in any of the triad of symptoms), and assessed gender-based disparities in treatment.
methodsWe conducted a multicenter retrospective chart review across three hospitals, identifying patients with radiologic evidence of NPH between 2019 and 2023. We recorded symptom burden, intervention rates (shunt placement or lumbar puncture), and post-intervention outcomes.
resultsAmong 385 included patients, both intervention rates and response to therapy increased with symptom count. Gender differences were noted, with men more likely to receive treatment. However, improvement rates did not significantly differ based on the number of symptoms.
conclusionOf all patients with radiology findings of normal pressure hydrocephalus, 317 (82.3%) had at least one symptom classically associated with NPH. A proportion of iNPH patients may be undertreated. Symptom burden and gender disparities appear to influence clinical decision-making and warrant further investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.