Evidence map›Paper›PMID 40837890›Full record

ArticleCureus2025

A Rare Case of Pneumomediastinum and Subcutaneous Emphysema Secondary to Recreational Nitrous Oxide Inhalation.

Nicole C Oparaugo, Jay Cadavona, Sean D Delshad

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nicole C OparaugoInternal Medicine, University of California, Irvine, Irvine, USA.
Jay CadavonaHospital Medicine, University of California, Los Angeles, Los Angeles, USA.
Sean D DelshadHospital Medicine, University of California, Los Angeles, Los Angeles, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recreational inhalation of nitrous oxide, also known as laughing gas, continues to rise due to its euphoric effects and easy accessibility. Clinicians may therefore encounter patients suffering from the potential adverse effects of nitrous oxide inhalation more commonly. We present a case of a 35-year-old man who presented with neck and facial swelling and pleuritic chest pain after a two-day recreational binge of nitrous oxide inhalation. The patient was found to have subcutaneous emphysema and pneumomediastinum, rare adverse effects of nitrous oxide inhalation. The patient's symptoms improved with supportive care.

Indexed as

laughing gasnitrous oxidepneumomediastinumrecreational drug usesubcutaneous emphysemasubstance use disorder (sud)

Identifiers

PMID40837890
PMCPMC12361542

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.