ArticleFrontiers in aging neuroscience2025
Distinct effect of partial sleep deprivation associated with gray matter changes in young and old adults.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Background: Sleep deprivation (SD) exerts adverse effects on human brain. However, whether there were distinct effects of partial SD associated with gray matter changes in young and old adults, respectively, remains unclear. Methods: 42 young adults and 38 old adults were enrolled in this study. All participants underwent MRI scanning, and FreeSurfer 5.3 was used to calculate cortical thickness (CT) and cortical surface area (CSA). Paired two samples Results: Young adults exhibited increased biopsychological response (Sickness-Q score) following partial SD compared to the rested condition, and similar trend was observed in old adults in SD. Young adults exhibited decreased CSA of left caudal middle frontal cortex and CT of entorhinal cortex (EC), but increased CSA of left temporal pole and CT of right insula after SD. However, old adults showed increased CSA and CT in widespread brain regions, including left superior frontal cortex, left isthmus cingulate cortex and right EC. While young adults showed a significant positive correlation between percent change of CSA of left EC and the biopsychological response, old adults showed a significant negative correlation between percentage change in CT of the left isthmus cingulate cortex and biopsychological response. Conclusion: Distinct effect of partial SD associated with gray matter changes were observed in young and old adults, respectively. These findings shed light on SD might affect brain structures differently in young adults and old adults.
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