ArticleFrontiers in aging neuroscience2025
Clinical mechanisms of repetitive transcranial magnetic stimulation in improving constipation in Parkinson's disease patients through the gut-brain axis.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 authors.
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Abstract
Objectives: This study investigates the clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) in alleviating constipation in patients with Parkinson's disease (PD) via the gut-brain axis. Methods: Fifty-eight PD patients with constipation, admitted from May 2023 to December 2024, were randomly assigned to an rTMS treatment group or a sham rTMS control group (29 patients each). Chronic constipation severity was assessed using the Chronic Constipation Severity Score (CSS) before and 14 days after treatment. Additional measures included weekly spontaneous bowel movements (SBM), complete spontaneous bowel movements (CSBM), the Bristol Stool Scale (BSS), and serum levels of gut-brain peptides (5-HT, BDNF, VIP) and cytokines (IL-6, IFN-γ, TNF-α, IL-4, IL-10). Results: Baseline characteristics, including CSS scores, were similar between groups ( Conclusion: Repetitive transcranial magnetic stimulation effectively improves constipation symptoms in PD patients over a 14 days period. These benefits are associated with favorable modulations of gut-brain peptides and cytokine profiles, suggesting a therapeutic mechanism involving the gut-brain axis. However, direct causality and the long-term effects require further investigation.
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