Evidence map›Paper›PMID 40837818›Full record

ArticleWorld journal of psychiatry2025

Informed consent competency assessment for brain-computer interface clinical research and application in psychiatric disorders: A systematic review.

Jia-Yue Si, Zi-Yan Lin, Di-Ga Gan, Xin-Yang Zhang, Yan-Nan Liu, Yu-Xin Hu, Yan-Ping Bao, Xue-Qin Wang, Hong-Qiang Sun, Xin Yu and 1 more

Abstract read
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In one paragraph

Article in World journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Ethics of brain-computer interface in mental healthcare.Frontiers in human neuroscience · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jia-Yue SiDepartment of Psychiatry, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing 100191, China.
Zi-Yan LinDepartment of Psychology, University of Toronto, Toronto M5S 1A1, Ontario, Canada.
Di-Ga GanDepartment of Psychiatry, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing 100191, China.
Xin-Yang ZhangDepartment of Psychiatry, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing 100191, China.
Yan-Nan LiuDepartment of Psychiatry, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing 100191, China.
Yu-Xin HuDepartment of Psychiatry, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing 100191, China.
Yan-Ping BaoDepartment of Epidemiology, National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing 100191, China.
Xue-Qin WangDepartment of Psychiatry, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing 100191, China. wangxueqin@bjmu.edu.cn.
Hong-Qiang SunDepartment of Psychiatry, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing 100191, China.
Xin YuDepartment of Psychiatry, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing 100191, China.
Lin LuDepartment of Psychiatry, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing 100191, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBrain-computer interface (BCI) technology is rapidly advancing in psychiatry. Informed consent competency (ICC) assessment among psychiatric patients is a pivotal concern in clinical research.

aimTo analyze the assessment of ICC and form a framework with multi-dimensional elements involved in ICC of BCI clinical research among psychiatric disorders.

methodsA systematic review of studies regarding ICC assessments of BCI clinical research in patients with six kinds of psychiatric disorders was conducted. A systematic literature search was performed using PubMed, ScienceDirect, and Web of Science. Peer-reviewed articles and full-text studies were included in the analysis. There were no date restrictions, and all studies published up to February 27, 2025, were included.

resultsA total of 103 studies were selected for this review. Fifty-eight studies included ICC factors, and forty-five were classified in ICC related ethical issues of BCI research in six kinds of psychiatric disorders. Executive function impairment is widely recognized as the most significant factor impacting ICC, and processing speed deficits are observed in schizophrenia, mood disorders, and Alzheimer's disease. Memory dysfunction, particularly episodic and working memory, contributes to compromised ICC. Five core ethical issues in BCI research should be addressed: BCI specificity, vulnerability, autonomy, dynamic ICC, comprehensiveness, and uncertainty.

conclusionA Five-Dimensional evaluative framework, including clinical, ethical, sociocultural, legal, and procedural dimensions, is constructed and proposed for future ICC research in BCI clinical research involving psychiatric disorders.

Indexed as

Brain-computer interfaceDecision-making capacityInformed consent competencyMacArthur Competence Assessment ToolPsychiatric disorders

Identifiers

PMID40837818
PMCPMC12362645

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.