Evidence map›Paper›PMID 40837774›Full record

ReviewWorld journal of gastrointestinal oncology2025

Lipid metabolism-related genes in gastric cancer: Exploring oncogenic pathways.

Maaz Amir, Danyal Bakht, Syed Faqeer Hussain Bokhari, Rabia Yousaf, Asma Iqbal, Hashir Nazir, Muhammad Waleed, Mustabeen Zahra Naqvi, Maleeha Tahir, Wahidullah Dost

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Acetate Metabolism in Thyroid Cancer Progression.International journal of molecular sciences · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maaz AmirDepartment of Medicine and Surgery, King Edward Medical University, Lahore 54000, Punjab, Pakistan.
Danyal BakhtDepartment of Medicine and Surgery, King Edward Medical University, Lahore 54000, Punjab, Pakistan.
Syed Faqeer Hussain BokhariDepartment of Medicine and Surgery, King Edward Medical University, Lahore 54000, Punjab, Pakistan.
Rabia YousafDepartment of Medicine and Surgery, Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad 46000, Pakistan.
Asma IqbalDepartment of Medicine and Surgery, King Edward Medical University, Lahore 54000, Punjab, Pakistan.
Hashir NazirDepartment of Medicine and Surgery, King Edward Medical University, Lahore 54000, Punjab, Pakistan.
Muhammad WaleedDepartment of Medicine and Surgery, King Edward Medical University, Lahore 54000, Punjab, Pakistan.
Mustabeen Zahra NaqviDepartment of Medicine and Surgery, King Edward Medical University, Lahore 54000, Punjab, Pakistan.
Maleeha TahirDepartment of Medicine and Surgery, King Edward Medical University, Lahore 54000, Punjab, Pakistan.
Wahidullah DostCurative Medicine, Kabul University of Medical Sciences, Kabul 10001, Afghanistan. wahidullahdost96@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipid metabolism plays a pivotal role in gastric cancer (GC) progression, characterized by complex metabolic reprogramming that supports tumor growth and survival. This narrative review comprehensively examines the dysregulation of lipid metabolism-associated genes, including fatty acid synthase (FASN), ATP-citrate lyase, acetyl-CoA carboxylases, FA binding proteins, sterol regulatory element-binding proteins, and other key enzymes. These genes facilitate critical oncogenic processes by enhancing FA synthesis, modifying cellular signaling, and supporting cancer cell proliferation, migration, and therapy resistance. Metabolic adaptations observed in GC include increased

Indexed as

Fatty acid synthesisGastric cancerLipid metabolismMetabolic reprogrammingOncogenic pathways

Identifiers

PMID40837774
PMCPMC12362529

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.