ArticleWorld journal of gastrointestinal oncology2025
Diet and physical activity in colorectal cancer patients: A research protocol of a randomized controlled study.
Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06194786 (Diet and Physical Activity Program in Colorectal Cancer Survivor), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diet and Physical Activity Program in Colorectal Cancer Survivor: a Randomized Controlled Trial
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs the population of colorectal cancer (CRC) survivors continues to grow, the demand for effective, evidence-based post-treatment strategies becomes increasingly urgent. Despite robust evidence linking lifestyle factors to cancer outcomes, there remains no established consensus on the optimal nutritional and physical activity (PA) guidelines for disease-free CRC survivors.
aimTo demonstrate that structured lifestyle interventions, specifically tailored dietary and PA programs, can significantly improve behavioral targets as well as disease-free and overall survival (OS).
methodsWe designed a 2 × 2 factorial phase II randomized controlled trial to compare the effects of dietary and PA interventions with standard care.
resultsA total of 300 CRC survivors in complete remission will be recruited from oncology centers in Misurata and Zliten (Libya) and the Habib Bourguiba University Hospital (Tunisia). Participants will be randomized into four groups: Combined intervention, diet-only, PA-only, or usual care. They will be followed for 24 months, with outcomes including disease-free survival, OS, and quality of life. Ethical approval has been obtained (Sfax ID: 61/24; Misurata ID: 04/2023), and the trial is registered at ClinicalTrials.gov (NCT06194786).
conclusionThis study will provide crucial region-specific evidence on the feasibility and effectiveness of lifestyle interventions in CRC survivorship care. By evaluating the role of a high-fiber, low-red meat diet and structured PA, we aim to demonstrate the potential of these behaviors to improve survival outcomes and support their integration into future clinical practice guidelines.
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