ArticleWorld journal of gastrointestinal oncology2025
Tumor markers and multimodal magnetic resonance imaging in predicting rectal cancer stage and differentiation.
Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Transrectal Biplane Ultrasound Features and Clinical Characteristics Associated With T3-T4 Staging of Rectal Cancer: A Retrospective Study.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
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Abstract
backgroundRectal cancer is one of the common digestive system malignant tumors around the world. Its early diagnosis and staging are crucial for rectal cancer treatment and prognosis. In recent years, tumor markers have gradually received attention in early screening, treatment monitoring and prognostic evaluation of cancer, but their predictive role in rectal cancer staging and differentiation is still unclear.
aimTo assess the prognostic value of tumor markers alpha-fetoprotein (AFP) cancer antigen 72-4 (CA72-4), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA), alongside multimodal magnetic resonance imaging (MRI), for staging and differentiating rectal cancer in patients.
methodsThis study retrospectively analyzed 167 patients with rectal cancer who were treated at our institution from January 2020 to December 2024. Each patient underwent serological testing and multimodal MRI for diagnosis. Histopathological examination after surgical resection or imaging based on follow-up was used as the gold standard. According to the T stage and differentiation degree, patients were divided into low stage group (T1-T2) and high stage group (T3-T4). In addition, they were divided into low-differentiation groups and high-differentiation groups according to their differentiation degree. We compared the accuracy, sensitivity and specificity of tumor marker levels and MRI in rectal cancer stage and differentiation.
resultsThe study's findings indicate that in the context of rectal cancer T staging, there is substantial concordance between MRI and clinicopathological assessments, with a Kappa coefficient of 0.789 (
conclusionThe CA19-9, CA72-4, CEA and AFP tumor markers combined with multimodal MRI have high sensitivity and specificity in diagnosing rectal cancer stage and differentiation. Their diagnostic efficacy is significantly better than that of single tests, which can effectively improve the predictive ability of rectal cancer stage and differentiation, provide a more reliable diagnostic reference for clinical practice, and have important clinical significance.
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