Evidence map›Paper›PMID 40837687›Full record

ReviewEnvironment & health (Washington, D.C.)2025

Staged Construction of Pluripotent Stem Cell Lung Models for Assessing Respiratory Toxicity of Environmental Pollutants.

Shuxian Zhang, Renjun Yang, Nuoya Yin, Francesco Faiola

Abstract readReview
In one paragraph

Review in Environment & health (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shuxian ZhangState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Renjun YangState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.ORCID https://orcid.org/0000-0002-9353-5041
Nuoya YinState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.ORCID https://orcid.org/0000-0003-1715-5255
Francesco FaiolaState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.ORCID https://orcid.org/0000-0002-3512-8253

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to factors such as smoking, air pollution, and an aging population, the prevention and control of chronic respiratory diseases in China are becoming more severe. Combining current epidemiological investigations, exposure to environmental pollutants such as atmospheric pollutants, persistent organic pollutants, and heavy metals may have adverse effects on lung development. Lung differentiation models are crucial tools for elucidating the process of lung development. Through the combined effect of various cell growth factors and small molecules, pluripotent stem cells are successively induced to the definitive endoderm, the anterior foregut endoderm, lung progenitor cells, and alveolar epithelial cells and eventually form matured lung alveolar organoids, revealing the complex mechanisms of lung tissue formation. This Review compares various differentiation schemes based on

Indexed as

Alveolar organoidsEnvironmental pollutionLung differentiation modelPluripotent stem cellRespiratory diseases

Identifiers

PMID40837687
PMCPMC12362214

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.