ArticleFrontiers in pediatrics2025
Vitamin D and calcium-phosphorus in serum of children with celiac disease in a zone of high sunlight exposure.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Actuality: The relationship between vitamin D levels and celiac disease (CeD) in children remains controversial. Uzbekistan is a country where the average number of sunny days is more than 300 days. There are few studies on the vitamin D status of children with celiac disease in an area of high insolation. Aim of the study: To determine vitamin D status in children with CeD and to evaluate clinical and laboratory parameters in children depending on vitamin D levels. Patients and methods: We examined 60 children with first diagnosed CeD aged from 1 to 16 years, the average age was 6 ± 2.3 years. The diagnosis was established on the basis of ESPGHAN 2012 criteria. In all children serum 25(OH)D, calcium, phosphorus, parathormone, alkaline phosphatase was determined. The control group consisted of 31 children of identical age. Results: Children with CeD had significantly lower mean serum 25(OH)D levels (14.8 ± 1.04 ng/ml) compared to controls (45.1 ± 8.04 ng/ml; Conclusion: Children with celiac disease living in a region with increased sun light exposure showed a high prevalence of vitamin D deficiency. In our study, vitamin D deficiency in patients with celiac disease was associated with more severe clinical manifestations.
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